Inflammation is an evolutionarily selected defense response to infection or tissue damage
that involves activation and consumption of immune cells in order to reestablish and …

Hematopoietic stem cell (HSC) aging was originally thought to be essentially an HSC-
autonomous process, which is the focus of another review in the same issue of …

Aging is associated with impaired hematopoietic and immune function caused in part by
decreased fitness in the hematopoietic stem cell (HSC) population and an increased …

Background Vascular activation is characterized by increased proinflammatory, pro
thrombotic, and proadhesive signaling. Several chronic and acute conditions, including Bcr …

Hematopoietic stem cells (HSCs) are capable of entering the cell cycle to replenish the
blood system in response to inflammatory cues; however, excessive proliferation in …

Hematopoietic stem cells (HSCs) sustain the lifelong production of all blood cell lineages.
The functioning of aged HSCs is impaired, including a declined repopulation capacity and …

Simple Summary The bone marrow (BM) microenvironment regulates normal hematopoiesis
and exerts variable activity in various inflammatory, toxic, autoimmune, or neoplastic …

Ageing is characterized by a progressive loss of cellular function that leads to a decline in
tissue homeostasis, increased vulnerability and adverse health outcomes. Important …

Haematopoietic stem cells (HSCs) reside in the bone marrow and are supported by the
specialised microenvironment, a niche to maintain HSC quiescence. To deal with …

Abstract Purpose of Review Inflammatory signals have emerged as critical regulators of
hematopoietic stem cell (HSC) function. Specifically, HSCs are highly responsive to acute …