The role of vascular smooth muscle cells in the development of aortic aneurysms and dissections
KB Rombouts, TAR van Merrienboer… - European journal of …, 2022 - Wiley Online Library
Background Aortic aneurysms (AA) are pathological dilations of the aorta, associated with
an overall mortality rate up to 90% in case of rupture. In addition to dilation, the aortic layers …
an overall mortality rate up to 90% in case of rupture. In addition to dilation, the aortic layers …
Vascular smooth muscle cells in aortic aneurysm: from genetics to mechanisms
Aortic aneurysm, including thoracic aortic aneurysm and abdominal aortic aneurysm, is the
second most prevalent aortic disease following atherosclerosis, representing the ninth …
second most prevalent aortic disease following atherosclerosis, representing the ninth …
Single-cell transcriptome analysis reveals dynamic cell populations and differential gene expression patterns in control and aneurysmal human aortic tissue
Background: Ascending thoracic aortic aneurysm (ATAA) is caused by the progressive
weakening and dilatation of the aortic wall and can lead to aortic dissection, rupture, and …
weakening and dilatation of the aortic wall and can lead to aortic dissection, rupture, and …
[HTML][HTML] The mechanism and therapy of aortic aneurysms
Aortic aneurysm is a chronic aortic disease affected by many factors. Although it is generally
asymptomatic, it poses a significant threat to human life due to a high risk of rupture …
asymptomatic, it poses a significant threat to human life due to a high risk of rupture …
Smooth muscle cell phenotypic diversity: At the crossroads of lineage tracing and single-cell transcriptomics
M Liu, D Gomez - Arteriosclerosis, thrombosis, and vascular …, 2019 - Am Heart Assoc
Vascular smooth muscle cells (SMC) play a critical role in controlling blood pressure and
blood distribution, as well as maintaining the structural integrity of the blood vessel. SMC …
blood distribution, as well as maintaining the structural integrity of the blood vessel. SMC …
Legumain is an endogenous modulator of integrin αvβ3 triggering vascular degeneration, dissection, and rupture
Background: The development of thoracic aortic dissection (TAD) is closely related to
extracellular matrix degradation and vascular smooth muscle cell (VSMC) transformation …
extracellular matrix degradation and vascular smooth muscle cell (VSMC) transformation …
[HTML][HTML] Targeting smooth muscle cell phenotypic switching in vascular disease
Objective The phenotypic plasticity of vascular smooth muscle cells (VSMCs) is central to
vessel growth and remodeling, but also contributes to cardiovascular pathologies. New …
vessel growth and remodeling, but also contributes to cardiovascular pathologies. New …
Prevention of aortic dissection and aneurysm via an ALDH2-mediated switch in vascular smooth muscle cell phenotype
K Yang, J Ren, X Li, Z Wang, L Xue, S Cui… - European heart …, 2020 - academic.oup.com
Aims Aortic aneurysm/dissection (AAD) is a life-threatening disorder lacking effective
pharmacotherapeutic remedies. Aldehyde dehydrogenase 2 (ALDH2) polymorphism is tied …
pharmacotherapeutic remedies. Aldehyde dehydrogenase 2 (ALDH2) polymorphism is tied …
Epigenetic induction of smooth muscle cell phenotypic alterations in aortic aneurysms and dissections
BACKGROUND: Smooth muscle cell (SMC) phenotypic switching has been increasingly
detected in aortic aneurysm and dissection (AAD) tissues. However, the diverse SMC …
detected in aortic aneurysm and dissection (AAD) tissues. However, the diverse SMC …
Aortic aneurysms and dissections series
YH Shen, SA LeMaire, NR Webb… - … , and vascular biology, 2020 - Am Heart Assoc
The aortic wall is composed of highly dynamic cell populations and extracellular matrix. In
response to changes in the biomechanical environment, aortic cells and extracellular matrix …
response to changes in the biomechanical environment, aortic cells and extracellular matrix …