Saga of Mcl-1: regulation from transcription to degradation
VV Senichkin, AY Streletskaia, AS Gorbunova… - Cell Death & …, 2020 - nature.com
The members of the Bcl-2 family are the central regulators of various cell death modalities.
Some of these proteins contribute to apoptosis, while others counteract this type of …
Some of these proteins contribute to apoptosis, while others counteract this type of …
Ubiquitination and deubiquitination of MCL1 in cancer: deciphering chemoresistance mechanisms and providing potential therapeutic options
MCL1 is an important antiapoptotic member of the BCL-2 family that is distinguishable from
other family members based on its relatively short half-life. Emerging studies have revealed …
other family members based on its relatively short half-life. Emerging studies have revealed …
Genetic alterations of TRAF proteins in human cancers
S Zhu, J Jin, S Gokhale, AM Lu, H Shan… - Frontiers in …, 2018 - frontiersin.org
The tumor necrosis factor receptor (TNF-R)-associated factor (TRAF) family of cytoplasmic
adaptor proteins regulate the signal transduction pathways of a variety of receptors …
adaptor proteins regulate the signal transduction pathways of a variety of receptors …
Role of K63-linked ubiquitination in cancer
L Cao, X Liu, B Zheng, C Xing, J Liu - Cell death discovery, 2022 - nature.com
Ubiquitination is a critical type of post-translational modifications, of which K63-linked
ubiquitination regulates interaction, translocation, and activation of proteins. In recent years …
ubiquitination regulates interaction, translocation, and activation of proteins. In recent years …
Skp2 stabilizes Mcl-1 and confers radioresistance in colorectal cancer
X Yu, L Zhou, W Liu, L Liu, F Gao, W Li, H Liu - Cell Death & Disease, 2022 - nature.com
Overexpression of Skp2 plays a critical role in tumorigenesis and correlates with poor
prognosis in human malignancies. Thus, Skp2 has been proposed as an attractive target for …
prognosis in human malignancies. Thus, Skp2 has been proposed as an attractive target for …
The OX40-TRAF6 axis promotes CTLA-4 degradation to augment antitumor CD8+ T-cell immunity
J Yu, J Cui, X Zhang, H Xu, Z Chen, Y Li… - Cellular & Molecular …, 2023 - nature.com
Immune checkpoint blockade (ICB), including anti-cytotoxic T-lymphocyte associated protein
4 (CTLA-4), benefits only a limited number of patients with cancer. Understanding the in …
4 (CTLA-4), benefits only a limited number of patients with cancer. Understanding the in …
Understanding MCL1: from cellular function and regulation to pharmacological inhibition
M Sancho, D Leiva, E Lucendo, M Orzáez - The FEBS Journal, 2022 - Wiley Online Library
Myeloid cell leukemia‐1 (MCL1), an antiapoptotic member of the BCL2 family characterized
by a short half‐life, functions as a rapid sensor that regulates cell death and other relevant …
by a short half‐life, functions as a rapid sensor that regulates cell death and other relevant …
Co-Infection and Cancer: Host–Pathogen Interaction between Dendritic Cells and HIV-1, HTLV-1, and Other Oncogenic Viruses
Dendritic cells (DCs) function as a link between innate and adaptive immune responses.
Retroviruses HIV-1 and HTLV-1 modulate DCs to their advantage and utilize them to …
Retroviruses HIV-1 and HTLV-1 modulate DCs to their advantage and utilize them to …
NF‐κB signaling mechanisms in HTLV‐1‐induced adult T‐cell leukemia/lymphoma
The human T‐cell leukemia virus type 1 (HTLV‐1) is a complex deltaretrovirus linked to
adult T‐cell leukemia/lymphoma (ATLL), a fatal CD 4+ malignancy in 3–5% of infected …
adult T‐cell leukemia/lymphoma (ATLL), a fatal CD 4+ malignancy in 3–5% of infected …