Electronic cigarettes (e-cigarettes) were introduced in the United States in 2007 and by 2014
they were the most popular tobacco product amongst youth and had overtaken use of …

COPD is a heterogeneous disorder that shows diverse clinical presentations (phenotypes
and “treatable traits”) and biological mechanisms (endotypes). This heterogeneity implies …

Urinary mercapturic acids (MAs) are often used as biomarkers for monitoring human
exposures to occupational and environmental xenobiotics. In this study, we developed an …

Urinary mercapturic acids (MAs) are detoxification products for electrophiles occurring in the
human body. They are suitable biomarkers of exposure to directly acting electrophilic …

Despite efforts to eliminate smoking, more than 1 billion people worldwide continue to use
combustible cigarettes through choice or inability to quit. With an associated 8 million …

Pooled quality controls (QCs) are usually implemented within untargeted methods to
improve the quality of datasets by removing features either not detected or not reproducible …

With increasing use of new generation tobacco/nicotine products (TNPs) instead or in
addition to conventional cigarettes (CCs), the question arises, whether the user of these new …

To explore the etiology of diseases is one of the major goals in epidemiological study. Meet-
in-metabolite analysis reconstitutes biomonitoring-based adverse outcome (AO) pathways …

Background and aims Optimizing metabolomics data processing parameters is a
challenging and fundamental task to obtain reliable results. Automated tools have been …

Microscopic colitis (MC) is classified as collagenous colitis (CC) and lymphocytic colitis (LC).
Genetic associations between CC and human leucocyte antigens (HLAs) have been found …