A review on chikungunya virus epidemiology, pathogenesis and current vaccine development

TYV de Lima Cavalcanti, MR Pereira, SO de Paula… - Viruses, 2022 - mdpi.com
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that recently re-emerged in
many parts of the world causing large-scale outbreaks. CHIKV infection presents as a febrile …

Chikungunya virus: an update on the biology and pathogenesis of this emerging pathogen

FJ Burt, W Chen, JJ Miner, DJ Lenschow… - The Lancet Infectious …, 2017 - thelancet.com
Re-emergence of chikungunya virus, a mosquito-transmitted pathogen, is of serious public
health concern. In the past 15 years, after decades of infrequent, sporadic outbreaks, the …

Chikungunya fever: epidemiology, clinical syndrome, pathogenesis and therapy

SD Thiberville, N Moyen, L Dupuis-Maguiraga… - Antiviral research, 2013 - Elsevier
Chikungunya virus (CHIKV) is the aetiological agent of the mosquito-borne disease
chikungunya fever, a debilitating arthritic disease that, during the past 7 years, has caused …

[PDF][PDF] Chikungunya virus infection: an overview

C Caglioti, E Lalle, C Castilletti, F Carletti… - New …, 2013 - carivecnet.carpha.org
Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus belonging to the
Togaviridae family, first isolated in Tanzania in 1952. The main vectors are mosquitoes from …

Vaccine and therapeutic options to control chikungunya virus

AM Powers - Clinical microbiology reviews, 2018 - Am Soc Microbiol
Beginning in 2004, chikungunya virus (CHIKV) went from an endemic pathogen limited to
Africa and Asia that caused periodic outbreaks to a global pathogen. Given that outbreaks …

Inactivated viral vaccines

B Sanders, M Koldijk, H Schuitemaker - Vaccine analysis: strategies …, 2015 - Springer
Inactivated vaccines have been used for over a century to induce protection against viral
pathogens. This established approach of vaccine production is relatively straightforward to …

A chikungunya fever vaccine utilizing an insect-specific virus platform

JH Erasmus, AJ Auguste, JT Kaelber, H Luo… - Nature medicine, 2017 - nature.com
Traditionally, vaccine development involves tradeoffs between immunogenicity and safety.
Live-attenuated vaccines typically offer rapid and durable immunity but have reduced safety …

Novel attenuated Chikungunya vaccine candidates elicit protective immunity in C57BL/6 mice

D Hallengärd, M Kakoulidou, A Lulla… - Journal of …, 2014 - Am Soc Microbiol
Chikungunya virus (CHIKV) is a reemerging mosquito-borne alphavirus that has caused
severe epidemics in Africa and Asia and occasionally in Europe. As of today, there is no …

Cellular and molecular immune response to chikungunya virus infection

ISB Tanabe, ELL Tanabe, EC Santos… - Frontiers in cellular …, 2018 - frontiersin.org
Chikungunya virus (CHIKV) is a re-emergent arthropod-borne virus (arbovirus) that causes a
disease characterized primarily by fever, rash and severe persistent polyarthralgia. In the …

Recent progress in vaccine development against chikungunya virus

S Gao, S Song, L Zhang - Frontiers in microbiology, 2019 - frontiersin.org
Chikungunya fever (CHIKF) is an acute infectious disease that is mediated by the mosquito-
transmitted chikungunya virus (CHIKV). People infected with CHIKV may experience high …