This chapter is an update of the data on substrates, reactions, inducers, and inhibitors of
human CYP enzymes published previously by Rendic and DiCarlo Citation 1a, Citation 1b …

Despite the fundamental importance of E. coli in the manufacture of a wide range of
biotechnological and biomedical products, extensive process and/or target optimisation is …

Abstract The cytochrome P450 (P450) enzymes first attracted interest because of their
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …

Much of P450 research has always been done with the view of appUcation to humans, even
when done with experimental animals and microorganisms. Research with the human …

Aiming at the development of new drugs for the treatment of prostate cancer, the effects of
steroidal compounds and one non-steroidal substance on androgen biosynthesis were …

In this study, the synthesis and biological evaluation of heteroaryl-substituted
dihydronaphthalenes and indenes (1− 16) is described. The compounds were tested for …

The design, synthesis, and biological evaluation of a series of new aromatase (AR, CYP19)
inhibitors bearing an imidazole ring linked to a 7-substituted coumarin scaffold at position 4 …

Recent reports described cases of severe hypertension and hypokalemia accompanied by
low renin and aldosterone levels during antifungal therapy with posaconazole and …

17α-Hydroxylase/C17− 20-lyase (P450 17, CYP 17) and 5α-reductase are the key enzymes
in androgen biosynthesis and targets for the treatment of prostate cancer and benign …

Pyridine substituted naphthalenes (eg, I− III) constitute a class of potent inhibitors of
aldosterone synthase (CYP11B2). To overcome the unwanted inhibition of the hepatic …