Regulated cell death mediated by dedicated molecular machines, known as programmed
cell death, plays important roles in health and disease. Apoptosis, necroptosis and …

Cell death research was revitalized by the understanding that necrosis can occur in a highly
regulated and genetically controlled manner. Although RIPK1 (receptor-interacting protein …

6-PPD quinone (6-PPDQ) can be transformed from 6-PPD through ozonation. Nevertheless,
the potential neurotoxicity of 6-PPDQ after long-term exposure and the underlying …

Purpose: The induced death signals following oncogene inhibition underlie clinical efficacy
of molecular targeted therapies against human cancer, and defects of intact cell apoptosis …

Lysosomes serve as the cellular recycling centre and are filled with numerous hydrolases
that can degrade most cellular macromolecules. Lysosomal membrane permeabilization …

Lysosomal membrane permeabilization (LMP) contributes to tissue involution, degenerative
diseases, and cancer therapy. Its investigation has, however, been hindered by the lack of …

Using Caenorhabditis elegans as an animal model, we investigated combinational effect
between 2-hydroxyatrazine (HA) and polystyrene nanoparticle (PS-NP) on function and …

Necrosis has been defined as a type of cell death that lacks the features of apoptosis and
autophagy, and is usually considered to be uncontrolled. Recent research suggests …

Organismal homeostasis depends on an intricate balance between cell death and renewal.
Early pathologists recognized that this balance could be disrupted by the extensive damage …

Cell death was once viewed as unregulated. It is now clear that at least a portion of cell
death is a regulated cell suicide process. This type of death can exhibit multiple …