Haematological malignancies were previously thought to be driven solely by genetic or
epigenetic lesions within haematopoietic cells. However, the niches that maintain and …

In contrast to solid cancers, which often require genetic modifications and complex cellular
reprogramming for effective metastatic dissemination, leukaemic cells uniquely possess the …

In many types of solid tumours, the aberrant expression of the cell adhesion molecule N-
cadherin is a hallmark of epithelial-to-mesenchymal transition, resulting in the acquisition of …

Tumor cells constantly interact with the surrounding microenvironment. Increasing evidence
indicates that targeting the tumor microenvironment could complement traditional treatment …

Hematopoietic stem cells (HSCs) rely on instructive cues from the bone marrow (BM) niche
to maintain their quiescence and adapt blood production to the organism's needs …

Relapse remains the major cause of mortality for patients with Acute Myeloid Leukemia
(AML). Improved tracking of minimal residual disease (MRD) holds the promise of timely …

Standard induction chemotherapy, consisting of an anthracycline and cytarabine, has been
the first-line therapy for many years to treat acute myeloid leukemia (AML). Although this …

Acute myeloid leukemia (AML) is a highly heterogeneous hematopoietic malignancy
characterized by excessive proliferation and accumulation of immature myeloid blasts in the …

Acute myeloid leukemia (AML) is one of the most common types of leukemia in adults. While
complete remission can be obtained with intensive chemotherapy in young and fit patients …

Galectin 3 is a member of a family of β-galactoside binding proteins and has emerged as an
important regulator of diverse functions critical in cancer biology including apoptosis …