Asthma is a complex and heterogeneous chronic inflammatory disease of the airways.
Alongside environmental factors, asthma susceptibility is strongly influenced by genetics …

Adipose tissue is a dynamic and metabolically active organ that plays a crucial role in
energy homeostasis and endocrine function. Recent advancements in lipidomics techniques …

To identify genetic determinants of airway dysfunction, we performed a transcriptome-wide
association study for asthma by combining RNA-seq data from the nasal airway epithelium …

Background Nothing is known about the mechanisms by which increased ceramide levels in
the lung contribute to allergic responses and asthma severity. Objective We sought to …

Biological membranes consist of a lipid bilayer in which integral membrane proteins are
embedded. Based on the compositional complexity of the lipid species found in membranes …

Objective Genome-wide association studies identified ORMDL3 as an obesity-related gene,
and its expression was negatively correlated with body mass index. However, the precise …

Orosomucoid like 3 (ORMDL3) encodes an ER-resident transmembrane protein that
regulates the activity of serine palmitoyltransferase (SPT), the first and rate-limiting enzyme …

Obesity is a key risk factor for the development of metabolic disease. Bioactive sphingolipid
metabolites are among the lipids increased in obesity. Obesogenic saturated fatty acids are …

The serine palmitoyltransferase (SPT) complex catalyzes the rate-limiting step in the de
novo biosynthesis of ceramides, the precursors of sphingolipids. The mammalian ORMDL …

Asthma associated with obesity is a chronic disease that poses a threat to health in children
and results in severe wheezing, earlier airway remodeling and increased insensitivity to …