Successful vaccine development for infectious diseases has largely been achieved in
settings where natural immunity to the pathogen results in clearance in at least some …

In this brief review and perspective, we address the question of whether the immune
responses that bring about immune control of acute HIV infection are the same as, or distinct …

Virus-specific CD8+ T cells probably mediate control over HIV replication in rare individuals,
termed long-term nonprogressors (LTNPs) or elite controllers. Despite extensive …

Identifying the functions of human immunodeficiency virus (HIV)-specific CD8+ T cells that
are not merely modulated by the level of virus but clearly distinguish patients with immune …

The control of human immunodeficiency virus type 1 (HIV-1) associated with particular HLA
class I alleles suggests that some CD8+ T-cell responses may be more effective than others …

Interactions between Th17 cells, T-reg, and cells of the innate immune system influence the
course of HIV and SIV infection from its earliest stages, even before the appearance of …

The cytoplasmic TRIM5α proteins of certain mammalian lineages efficiently recognize the
incoming capsids of particular retroviruses and potently restrict infection in a species-specific …

The complex interplay between the host immune response and HIV has been the subject of
intense research over the last 25 years. HIV and simian immunodeficiency virus (SIV) CD8+ …

Specific major histocompatibility complex (MHC) class I alleles are associated with an
increased frequency of spontaneous control of human and simian immunodeficiency viruses …

Developing an effective HIV-1 vaccine will require strategies to enhance antigen
presentation to the immune system. In a previous study we demonstrated a marked increase …