DNA vaccines have evolved greatly over the last 20 years since their invention, but have yet
to become a competitive alternative to conventional protein or carbohydrate based human …

Interferon (IFN)-γ, is not only a marker of TH1 CD4, CD8 and natural killer (NK) cells, it is
also a critical antiviral mediator which is central to the elimination of viruses from the CNS. In …

Human cytomegalovirus (HCMV) has become a paradigm for viral immune evasion due to
its unique multitude of immune-modulatory strategies. HCMV modulates the innate as well …

To define immune mechanisms that regulate chronic and latent herpesvirus infection, we
analyzed the role of interferon γ (IFN-γ) during murine cytomegalovirus (MCMV) infection …

Viruses have evolved elaborate mechanisms to target many aspects of the host's immune
response. The cytokine IFN-γ plays a central role in resistance of the host to infection via …

Natural killer (NK) cells are critical for innate regulation of the acute phase of murine
cytomegalovirus (MCMV) infection and have been reported to utilize perforin (Pfp)-and …

Targeting therapeutic genes to the liver is essential to improve gene therapy protocols of
hepatic diseases and of some hereditary disorders. Transcriptional targeting can be …

The salivary glands represent a major site of cytomegalovirus replication and transmission
to other hosts. Despite control of viral infection by strong T cell responses in visceral organs …

Cationic lipid-mediated gene transfer to the mouse lung induces a dose-dependent
inflammatory response that is characterized by an influx of leukocytes and elevated levels of …

The use of mammalian gene expression vectors has become increasingly important for
transgenics and gene therapy as well as basic research. Essential for the success of these …