Diffusion within bacteria is often thought of as a “simple” random process by which
molecules collide and interact with each other. New research however shows that this is far …

Bistable switches are common gene regulatory motifs directing two mutually exclusive cell
fates. Theoretical studies suggest that bistable switches are sufficient to encode more than …

Single-molecule localization microscopy (SMLM) relies on the blinking behavior of a
fluorophore, which is the stochastic switching between fluorescent and dark states. Blinking …

HU (Histone‐like protein from Escherichia coli strain U93) is the most conserved nucleoid‐
associated protein in eubacteria, but how it impacts global chromosome organization is …

Understanding the phenotypic heterogeneity of antibiotic‐resistant bacteria following
treatment and the transitions between different phenotypes is crucial for developing effective …

Single-particle tracking experiments have measured escape times of DNA-binding species
diffusing in living cells: CRISPR-Cas9, TetR, and LacI. The observed distribution is a …

In single-molecule localization based super-resolution microscopy (SMLM), a fluorophore
stochastically switches between fluorescent-and dark-states, leading to intermittent emission …

Part I: SMLM provides not only high-resolution images of molecular assemblies beyond the
diffraction limit but also enables quantitative analysis of the dynamics and compositions …

Diffusion is at the heart of every biochemical process. Millions of proteins must navigate the
heterogeneous, crowded cellular milieu to perform their various tasks. This molecular …

In recent years the development of superresolution fluorescence microscopy has enabled
the probing of 29 macromolecular assemblies in cells with nanometer resolutions. Amongst …