Purinergic signalling, ie, the role of nucleotides as extracellular signalling molecules, was
proposed in 1972. However, this concept was not well accepted until the early 1990's when …

Purines appear to be the most primitive and widespread chemical messengers in the animal
and plant kingdoms. The evidence for purinergic signalling in plants, invertebrates and …

Purinergic signaling was proposed in 1972, after it was demonstrated that adenosine 5′-
triphosphate (ATP) was a transmitter in nonadrenergic, noncholinergic inhibitory nerves …

This review is focused on the pathophysiology and therapeutic potential of purinergic
signalling. A wide range of diseases are considered, including those of the central nervous …

As an analog to the endothelium situated next to the vascular smooth muscle, the epithelium
is emerging as an important regulator of smooth muscle contraction in many vital …

Bladder pain syndrome (BPS) is a clinical syndrome of pelvic pain and urinary urgency-
frequency in the absence of a specific cause. Investigating the expression levels of genes …

BACKGROUND: There is increased evidence to suggest a role for nonadrenergic–
noncholinergic neurotransmission in the pathogenesis of bladder dysfunction. OBJECTIVE …

There are multiple roles for purinergic signalling in both male and female reproductive
organs. ATP, released as a cotransmitter with noradrenaline from sympathetic nerves …

Purinergic effects in vivo are local, specific, transient, and affect target cells in a paracrine or
autocrine manner. Purinergic signalling is involved in the regulation of numerous functions …

OBJECTIVE To investigate whether ageing and diabetes alter the expression of the gap
junction protein connexin43 (Cx43) and of particular purinoceptor (P2R) subtypes in the …