[HTML][HTML] Integrated gradient tissue-engineered osteochondral scaffolds: Challenges, current efforts and future perspectives

X Niu, N Li, Z Du, X Li - Bioactive Materials, 2023 - Elsevier
The osteochondral defect repair has been most extensively studied due to the rising
demand for new therapies to diseases such as osteoarthritis. Tissue engineering has been …

Hydrogel drug delivery systems for bone regeneration

L Bai, G Tao, M Feng, Y Xie, S Cai, S Peng, J Xiao - Pharmaceutics, 2023 - mdpi.com
With the in-depth understanding of bone regeneration mechanisms and the development of
bone tissue engineering, a variety of scaffold carrier materials with desirable …

3D-bioprinted anisotropic bicellular living hydrogels boost osteochondral regeneration via reconstruction of cartilage–bone interface

Y Zhang, D Li, Y Liu, L Peng, D Lu, P Wang, D Ke… - The Innovation, 2024 - cell.com
Reconstruction of osteochondral (OC) defects represents an immense challenge due to the
need for synchronous regeneration of special stratified tissues. The revolutionary innovation …

A one‐stone‐two‐birds strategy for osteochondral regeneration based on a 3d printable biomimetic scaffold with kartogenin biochemical stimuli gradient

W Wei, W Liu, H Kang, X Zhang, R Yu… - Advanced …, 2023 - Wiley Online Library
Osteochondral defect (OCD) regeneration remains challenging because of the hierarchy of
the native tissue including both the articular cartilage and the subchondral bone …

Tough Polyurethane Hydrogels with a Multiple Hydrogen‐Bond Interlocked Bicontinuous Phase Structure Prepared by In Situ Water‐Induced Microphase Separation

R Wang, T Xu, Y Yang, M Zhang, R Xie… - Advanced …, 2024 - Wiley Online Library
Hydrogels with mechanical performances similar to load‐bearing tissues are in demand for
in vivo applications. In this work, inspired by the self‐assembly behavior of amphiphilic …

Gradient Modulus Strategy for Alleviating Stretchable Electronic Strain Concentration

B Sun, Z Li, Z Song, Y Yu, Z Zhang… - Advanced Functional …, 2024 - Wiley Online Library
The island‐bridge structural design is a common strategy for imparting stretchability to
flexible electronic devices. In this structure, the low modulus regions bear most of the …

Gradient scaffolds for osteochondral tissue engineering and regeneration

Z Xiong, F Hong, Z Wu, Y Ren, N Sun, BC Heng… - Chemical Engineering …, 2024 - Elsevier
In recent years, the incidence of osteoarthritis (OA) has been increasing worldwide. This
disease not only affects the articular cartilage but also impairs the subchondral bone and …

Understanding the mechanics of the temporomandibular joint osteochondral interface from micro-and nanoscopic perspectives

Z Su, P Tan, J Zhang, P Wang, S Zhu, N Jiang - Nano Letters, 2023 - ACS Publications
The condylar cartilage of the temporomandibular joint (TMJ) is connected to the subchondral
bone by an osteochondral interface that transmits loads without causing fatigue damage …

Stage-specific and location-specific cartilage calcification in osteoarthritis development

X Wang, Q Wu, R Zhang, Z Fan, W Li, R Mao… - Annals of the …, 2023 - ard.bmj.com
Objectives This study investigated the stage-specific and location-specific deposition and
characteristics of minerals in human osteoarthritis (OA) cartilages via multiple nano …

Progress in osteochondral regeneration with engineering strategies

H Gao, Q Pan, W Dong, Y Yao - Annals of Biomedical Engineering, 2022 - Springer
Osteoarthritis, the main cause of disability worldwide, involves not only cartilage injury but
also subchondral bone injury, which brings challenges to clinical repair. Tissue engineering …