SLC7A11/xCT is an antiporter that mediates the uptake of extracellular cystine in exchange
for glutamate. Cystine is reduced to cysteine, which is a rate-limiting precursor in glutathione …

Ferroptosis is defined as an iron-dependent regulated form of cell death driven by lipid
peroxidation. In the past decade, it has been implicated in the pathogenesis of various …

Objectives Evidences demonstrate that sorafenib alleviates liver fibrosis via inhibiting HSC
activation and ECM accumulation. The underlying mechanism remains unclear. Ferroptosis …

Activated hepatic stellate cells (HSCs) are significant in liver fibrosis. Our past investigations
have shown that human umbilical cord mesenchymal stem cells (hucMSCs) and their …

Activation of hepatic stellate cells (HSCs) is a central event in the development of liver
fibrosis, and the elimination of activated HSCs is considered to be an effective anti-fibrotic …

Background Liver fibrosis is a major disease that threatens people's health around the
world. However, there is a lack of effective treatment to completely reverse liver fibrosis …

Recent evidence indicates ferroptosis is implicated in the pathophysiology of various liver
diseases; however, the organ-specific regulation mechanism is poorly understood. Here, we …

Conclusion: YAP determines whether MF-HSCs remain activated or become senescent. By
regulating this state transition, Yap controls both HSC fibrogenic activity and susceptibility to …

Molybdenum (Mo) is an essential trace element that exists in all tissues of the human body,
but excessive Mo intake has a toxic effect. Cadmium (Cd) is a widely known and harmful …

Ferroptosis is a widely known regulator of cell death in connection with the redox state as a
consequence of the depletion of glutathione or accumulation of lipid peroxidation. Hepatic …