There has been a debate for many years on whether muscular training is beneficial or
harmful for patients with myopathic disorders and the role of exercise training in the …

Myotonic dystrophy is caused by an expanded CTG repeat in the 3′ untranslated region of
the DM protein kinase (DMPK) gene. The expanded repeat triggers the nuclear retention of …

Muscle wasting and weakness occur frequently in patients with chronic renal failure. The
mechanism (s) by which these abnormalities occur is unclear. We hypothesized that such …

Abstract Myotonic dystrophy type 1 (DM1) and type 2 (DM2) are caused by genomic
expansions of CTG or CCTG repeats. When transcribed, these mutations give rise to repeat …

Myotonic dystrophy (DM) is a dominantly inherited neurodegenerative disorder for which
there is no cure or effective treatment. Investigation of DM pathogenesis has identified a …

Myotonic dystrophy type 1 (DM1) is caused by expansion of CTG repeats in the 3′ UTR of
the DMPK gene. Expression of CUG expansion (CUGexp) RNA produces a toxic gain of …

Myotonic dystrophy type 1 (DM1) and type 2 (DM2) are autosomal dominant multisystemic
disorders linked to two different genetic loci and characterized by several features including …

Objective: To evaluate the safety and tolerability of recombinant human insulin-like growth
factor 1 (rhIGF-1) complexed with IGF binding protein 3 (rhIGF-1/rhIGFBP-3) in patients with …

Alternative splicing of ASI residues (Ala3481–Gln3485) in the skeletal muscle ryanodine
receptor (RyR1) is developmentally regulated: the residues are present in adult ASI (+) …

Low-protein turnover conditions are usually associated with the adequate sparing of body
proteins, whereas in high-protein turnover conditions protein loss may proceed at a faster …