Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments

Z Yuan, Y Li, S Zhang, X Wang, H Dou, X Yu, Z Zhang… - Molecular cancer, 2023 - Springer
The malignant tumor is a multi-etiological, systemic and complex disease characterized by
uncontrolled cell proliferation and distant metastasis. Anticancer treatments including …

Glomerulonephritis: immunopathogenesis and immunotherapy

HJ Anders, AR Kitching, N Leung… - Nature Reviews …, 2023 - nature.com
Abstract 'Glomerulonephritis'(GN) is a term used to describe a group of heterogeneous
immune-mediated disorders characterized by inflammation of the filtration units of the kidney …

Causative or associative: A critical review of the role of advanced glycation end-products in bone fragility

TL Willett, P Voziyan, JS Nyman - Bone, 2022 - Elsevier
The accumulation of advanced glycation end-products (AGEs) in the organic matrix of bone
with aging and chronic disease such as diabetes is thought to increase fracture risk …

High-resolution visualization and quantification of nucleic acid–based therapeutics in cells and tissues using Nanoscale secondary ion mass spectrometry (NanoSIMS …

C He, MT Migawa, K Chen, TA Weston… - Nucleic Acids …, 2021 - academic.oup.com
Nucleic acid therapeutics (NATs) have proven useful in promoting the degradation of
specific transcripts, modifying gene expression, and regulating mRNA splicing. In each …

[HTML][HTML] Identification of tyrosine brominated extracellular matrix proteins in normal and fibrotic lung tissues

LC Cruz, A Habibovic, B Dempsey, MP Massafera… - Redox Biology, 2024 - Elsevier
Peroxidasin (PXDN) is a secreted heme peroxidase that catalyzes the oxidative crosslinking
of collagen IV within the extracellular matrix (ECM) via intermediate hypobromous acid …

Peroxidasin is required for full viability in development and for maintenance of tissue mechanics in adults

KE Peebles, KS LaFever, PS Page-McCaw, S Colon… - Matrix Biology, 2024 - Elsevier
Basement membranes are thin strong sheets of extracellular matrix. They provide
mechanical and biochemical support to epithelia, muscles, nerves, and blood vessels …

Mammalian peroxidasin (PXDN): From physiology to pathology

G Cheng, R Shi - Free Radical Biology and Medicine, 2022 - Elsevier
Heme-containing peroxidases catalyze the oxidation of a variety of substrates by consuming
hydrogen peroxide (H 2 O 2), and play diversified roles in physiology and pathology …

Peroxidasin mediates bromination of tyrosine residues in the extracellular matrix

B Bathish, M Paumann-Page, LN Paton… - Journal of Biological …, 2020 - ASBMB
Peroxidasin is a heme peroxidase that oxidizes bromide to hypobromous acid (HOBr), a
powerful oxidant that promotes the formation of the sulfilimine crosslink in collagen IV in …

Surface analysis by gas cluster ion beam XPS and ToF-SIMS tandem MS of 2-mercaptobenzoxazole corrosion inhibitor for brass

M Finšgar - Corrosion Science, 2021 - Elsevier
This work presents the first study on 2-mercaprobenzoxazole (MBOH) as a corrosion
inhibitor for brass in chloride solution. The corrosion inhibition effect was conclusively …

[HTML][HTML] Peroxidasin is associated with a mesenchymal-like transcriptional phenotype and promotes invasion in metastatic melanoma

CC Smith-Díaz, A Kumar, A Das, P Pace… - Free Radical Biology …, 2025 - Elsevier
Cutaneous melanoma is a highly invasive, heterogeneous and treatment resistant cancer.
It's ability to dynamically shift between transcriptional states or phenotypes results in an …