Modeling semiflexible polymer networks

CP Broedersz, FC MacKintosh - Reviews of Modern Physics, 2014 - APS
This is an overview of theoretical approaches to semiflexible polymers and their networks.
Such semiflexible polymers have large bending rigidities that can compete with the entropic …

Mechanical properties of the cytoskeleton and cells

AF Pegoraro, P Janmey… - Cold Spring Harbor …, 2017 - cshperspectives.cshlp.org
The cytoskeleton is the major mechanical structure of the cell; it is a complex, dynamic
biopolymer network comprising microtubules, actin, and intermediate filaments. Both the …

[HTML][HTML] Structural specializations of the sperm tail

MR Leung, J Zeng, X Wang, MC Roelofs, W Huang… - Cell, 2023 - cell.com
Sperm motility is crucial to reproductive success in sexually reproducing organisms.
Impaired sperm movement causes male infertility, which is increasing globally. Sperm are …

Tubulin acetylation protects long-lived microtubules against mechanical ageing

D Portran, L Schaedel, Z Xu, M Théry, MV Nachury - Nature cell biology, 2017 - nature.com
Long-lived microtubules endow the eukaryotic cell with long-range transport abilities. While
long-lived microtubules are acetylated on Lys40 of α-tubulin (αK40), acetylation takes place …

Nanoconfinement controls stiffness, strength and mechanical toughness of β-sheet crystals in silk

S Keten, Z Xu, B Ihle, MJ Buehler - Nature materials, 2010 - nature.com
Silk features exceptional mechanical properties such as high tensile strength and great
extensibility, making it one of the toughest materials known. The exceptional strength of …

Microtubules self-repair in response to mechanical stress

L Schaedel, K John, J Gaillard, MV Nachury… - Nature materials, 2015 - nature.com
Microtubules—which define the shape of axons, cilia and flagella, and provide tracks for
intracellular transport—can be highly bent by intracellular forces, and microtubule structure …

[HTML][HTML] The forces behind cell movement

R Ananthakrishnan, A Ehrlicher - International journal of biological …, 2007 - ncbi.nlm.nih.gov
Cell movement is a complex phenomenon primarily driven by the actin network beneath the
cell membrane, and can be divided into three general components: protrusion of the leading …

The cell as a material

KE Kasza, AC Rowat, J Liu, TE Angelini… - Current opinion in cell …, 2007 - Elsevier
To elucidate the dynamic and functional role of a cell within the tissue it belongs to, it is
essential to understand its material properties. The cell is a viscoelastic material with highly …

Emergent complexity of the cytoskeleton: from single filaments to tissue

F Huber, J Schnauß, S Rönicke, P Rauch… - Advances in …, 2013 - Taylor & Francis
Despite their overwhelming complexity, living cells display a high degree of internal
mechanical and functional organization which can largely be attributed to the intracellular …

Three-dimensional structure of kinetochore-fibers in human mitotic spindles

R Kiewisz, G Fabig, W Conway, D Baum, D Needleman… - Elife, 2022 - elifesciences.org
During cell division, kinetochore microtubules (KMTs) provide a physical linkage between
the chromosomes and the rest of the spindle. KMTs in mammalian cells are organized into …