Fundamental Neurochemistry Review: Microglial immunometabolism in traumatic brain injury

NR Strogulski, LV Portela, BM Polster… - Journal of …, 2023 - Wiley Online Library
Traumatic brain injury (TBI) is a devastating neurological disorder caused by a physical
impact to the brain that promotes diffuse damage and chronic neurodegeneration. Key …

Label-Free Techniques for Probing Biomolecular Condensates

KA Ibrahim, AS Naidu, H Miljkovic, A Radenovic… - ACS …, 2024 - ACS Publications
Biomolecular condensates play important roles in a wide array of fundamental biological
processes, such as cellular compartmentalization, cellular regulation, and other biochemical …

Aqueous Grown Quantum Dots with Robust Near-Infrared Fluorescence for Integrated Traumatic Brain Injury Diagnosis and Surgical Monitoring

M Jiao, X Li, H Liu, P Cai, X Yang, KJ McHugh… - ACS …, 2024 - ACS Publications
Surgical intervention is the most common first-line treatment for severe traumatic brain
injuries (TBIs) associated with high intracranial pressure, while the complexity of these …

[HTML][HTML] Shared inflammatory glial cell signature after stab wound injury, revealed by spatial, temporal, and cell-type-specific profiling of the murine cerebral cortex

C Koupourtidou, V Schwarz, H Aliee, S Frerich… - Nature …, 2024 - nature.com
Traumatic brain injury leads to a highly orchestrated immune-and glial cell response
partially responsible for long-lasting disability and the development of secondary …

KCNJ2 inhibition mitigates mechanical injury in a human brain organoid model of traumatic brain injury

JD Lai, JE Berlind, G Fricklas, C Lie, JP Urenda, K Lam… - Cell Stem Cell, 2024 - cell.com
Traumatic brain injury (TBI) strongly correlates with neurodegenerative disease. However, it
remains unclear which neurodegenerative mechanisms are intrinsic to the brain and which …

A short dasatinib and quercetin treatment is sufficient to reinstate potent adult neuroregenesis in the aged killifish

J Van Houcke, V Marien, C Zandecki, R Ayana… - npj Regenerative …, 2023 - nature.com
The young African turquoise killifish has a high regenerative capacity, but loses it with
advancing age, adopting several aspects of the limited form of mammalian regeneration. We …

Ribosome inactivation regulates translation elongation in neurons

B Popper, M Bürkle, G Ciccopiedi… - Journal of Biological …, 2024 - ASBMB
Cellular plasticity is crucial for adapting to ever-changing stimuli. As a result, cells
consistently reshape their translatome, and, consequently, their proteome. The control of …

[HTML][HTML] Blockage of ATGL-mediated breakdown of lipid droplets in microglia alleviates neuroinflammatory and behavioural responses to lipopolysaccharides

JL Robb, F Boisjoly, AI Machuca-Parra… - Brain, behavior, and …, 2025 - Elsevier
Lipid droplets (LD) are triglyceride storing organelles that have emerged as an important
component of cellular inflammatory responses. LD lipolysis via adipose triglyceride lipase …

Pharmacological upregulation of microglial lipid droplet alleviates neuroinflammation and acute ischemic brain injury

H Li, P Liu, S Deng, L Zhu, X Cao, X Bao, S Xia, Y Xu… - Inflammation, 2023 - Springer
Lipid droplets (LDs) were reported to play an important role in the modulation of
inflammation and various cellular processes among multiple cell types. However, LDs …

TDP-43 in nuclear condensates: where, how, and why

R Lang, RE Hodgson… - Biochemical Society …, 2024 - portlandpress.com
TDP-43 is an abundant and ubiquitously expressed nuclear protein that becomes
dysfunctional in a spectrum of neurodegenerative diseases. TDP-43's ability to phase …