Cellular therapies using regulatory T (Treg) cells are currently undergoing clinical trials for
the treatment of autoimmune diseases, transplant rejection and graft-versus-host disease. In …

Regulatory T cells (Treg cells) are a small subset of immune cells that are dedicated to
curbing excessive immune activation and maintaining immune homeostasis. Accordingly …

Regulatory T cells (Tregs) are a small yet critical subset of CD4+ T cells, which have the role
of maintaining immune homeostasis by, for example, regulating self-tolerance, tumor …

Autologous T cells that have been genetically modified to express a chimeric antigen
receptor (CAR) targeting the B cell antigen CD19 have yielded remarkable clinical …

Therapeutic gene transfer holds the promise of providing lasting therapies and even cures
for diseases that were previously untreatable or for which only temporary or suboptimal …

Cellular therapies with polyclonal regulatory T-cells (Tregs) in transplantation and
autoimmune diseases have been carried out in both animal models and clinical trials …

A normal hemostatic response to vascular injury requires both factor VIII (FVIII) and von
Willebrand factor (VWF). In plasma, VWF and FVIII normally circulate as a noncovalent …

Regulatory T cells are critical for maintaining immune tolerance. Recent studies have
confirmed their therapeutic suppressive potential to modulate immune responses in organ …

Autoimmune diseases affect roughly 5-10% of the total population, with women affected
more than men. The standard treatment for autoimmune or autoinflammatory diseases had …

Antigen-specific regulatory T cells (Tregs) engineered with chimeric antigen receptors
(CARs) are a potent immunosuppressive cellular therapy in multiple disease models and …