Although they were originally defined as haematopoietic-cell growth factors, colony-
stimulating factors (CSFs) have been shown to have additional functions by acting directly …

The production of hematopoietic cells is under the tight control of a group of hematopoietic
cytokines. Each cytokine has multiple actions mediated by receptors whose cytoplasmic …

Background Neutropenia and infection are major dose-limiting side effects of chemotherapy.
Previous studies have suggested that recombinant methionyl granulocyte colony-stimulating …

The importance of neutropenia in the risk of serious infection in patients with cancer who are
receiving cytotoxic chemotherapy was first recognized nearly 30 years ago1. Since then …

The term mucositis is coined to describe the adverse effects of radiation and chemotherapy
treatments. Mucositis is one of the most common adverse reactions encountered in radiation …

The bone marrow is an important dose-limiting cell renewal tissue for chemotherapy, wide-
field irradiation, and autologous bone marrow transplantion. Over the past 5–10 years a …

PURPOSE AND METHODS Doxorubicin alone or with dacarbazine (DTIC; AD) is
considered the best available therapy for metastatic adult sarcomas. Ifosfamide is active in …

Cytokines are key instigators and regulators of immune responses and therefore hold great
potential as targets for new therapeutic strategies. However, the selection of which cytokines …

A multitude of laboratory and clinical research studies of ulcerative oral mucositis induced by
cytotoxic cancer therapies have been reported during the past decade. However, a …

Deficiency of tristetraprolin (TTP), the prototype of the CCCH zinc finger proteins, results in a
complex inflammatory syndrome in mice. Most aspects of the syndrome are secondary to …