Fundamental biological features of spaceflight: advancing the field to enable deep-space exploration

E Afshinnekoo, RT Scott, MJ MacKay, E Pariset… - Cell, 2020 - cell.com
Research on astronaut health and model organisms have revealed six features of
spaceflight biology that guide our current understanding of fundamental molecular changes …

Update on the effects of microgravity on the musculoskeletal system

OJ Juhl IV, EG Buettmann, MA Friedman… - npj …, 2021 - nature.com
With the reignited push for manned spaceflight and the development of companies focused
on commercializing spaceflight, increased human ventures into space are inevitable …

The Space Omics and Medical Atlas (SOMA) and international astronaut biobank

EG Overbey, JK Kim, BT Tierney, J Park, N Houerbi… - Nature, 2024 - nature.com
Spaceflight induces molecular, cellular and physiological shifts in astronauts and poses
myriad biomedical challenges to the human body, which are becoming increasingly relevant …

Human health during space travel: state-of-the-art review

C Krittanawong, NK Singh, RA Scheuring, E Urquieta… - Cells, 2022 - mdpi.com
The field of human space travel is in the midst of a dramatic revolution. Upcoming missions
are looking to push the boundaries of space travel, with plans to travel for longer distances …

Long-term space nutrition: a scoping review

H Tang, HH Rising, M Majji, RD Brown - Nutrients, 2021 - mdpi.com
This scoping review aimed to identify current evidence and gaps in the field of long-term
space nutrition. Specifically, the review targeted critical nutritional needs during long-term …

The time course of disuse muscle atrophy of the lower limb in health and disease

EJO Hardy, TB Inns, J Hatt, B Doleman… - Journal of Cachexia …, 2022 - Wiley Online Library
Short, intermittent episodes of disuse muscle atrophy (DMA) may have negative impact on
age related muscle loss. There is evidence of variability in rate of DMA between muscles …

Astronaut omics and the impact of space on the human body at scale

LA Rutter, H Cope, MJ MacKay, R Herranz… - Nature …, 2024 - nature.com
Future multi-year crewed planetary missions will motivate advances in aerospace nutrition
and telehealth. On Earth, the Human Cell Atlas project aims to spatially map all cell types in …

[HTML][HTML] Long-term human spaceflight and inflammaging: Does it promote aging?

M Capri, M Conte, E Ciurca, C Pirazzini… - Ageing Research …, 2023 - Elsevier
Spaceflight and its associated stressors, such as microgravity, radiation exposure,
confinement, circadian derailment and disruptive workloads represent an unprecedented …

Advantages and limitations of current microgravity platforms for space biology research

F Ferranti, M Del Bianco, C Pacelli - Applied Sciences, 2020 - mdpi.com
Human Space exploration has created new challenges and new opportunities for science.
Reaching beyond the Earth's surface has raised the issue of the importance of gravity for the …

Increased mechanical loading through controlled swimming exercise induces bone formation and mineralization in adult zebrafish

S Suniaga, T Rolvien, A Vom Scheidt, IAK Fiedler… - Scientific Reports, 2018 - nature.com
Exercise promotes gain in bone mass through adaptive responses of the vertebrate
skeleton. This mechanism counteracts age-and disease-related skeletal degradation, but …