There exists a paucity of structural innovation and limited molecular diversity associated with
molecular frameworks in drug discovery and biomolecular imaging/chemical probe design …

Boron-containing compounds (BCC) have emerged as important pharmacophores. To date,
five BCC drugs (including boronic acids and boroles) have been approved by the FDA for …

Icosahedral carboranes in medicine are still an emerging class of compounds with potential
beneficial applications in drug design. These highly hydrophobic clusters are potential “new …

In recent years, several radioligands targeting prostate-specific membrane antigen (PSMA)
have been clinically introduced as a new class of theranostic radiopharmaceuticals for the …

Prostate-specific membrane antigen (PSMA) is an important cell-surface imaging biomarker
and therapeutic target in prostate cancer. The PSMA-targeted theranostic 177Lu-PSMA-617 …

Boron neutron capture therapy (BNCT) is a therapeutic modality which has been used for
the treatment of cancers, including brain and head and neck tumors. For effective treatment …

Derivatives of dicarba-closo-dodecaboranes and dicarba-nido-undecaboranes (carboranes)
are of increasing interest for modern medicinal chemistry and materials science. The …

Prostate-specific membrane antigen (PSMA) is highly overexpressed in most prostate
cancers and is clinically visualized using PSMA-specific probes incorporating glutamate …

Nearly two decades ago, Joe Coyle published a single-authored review with the provocative
title, The Nagging Question of the Function of N-Acetylaspartylglutamate (Coyle, 1997). In …

Carborane maleimides were prepared in good yields through the thermal cyclization of
maleamic acids prepared by the reaction of 3-amino-o-carborane with maleic or 3 …