The ongoing quest for the first total artificial heart as destination therapy

A Vis, M Arfaee, H Khambati, MS Slaughter… - Nature Reviews …, 2022 - nature.com
Many patients with end-stage heart disease die because of the scarcity of donor hearts. A
total artificial heart (TAH), an implantable machine that replaces the heart, has so far been …

Continuous-flow ventricular assist device support in adult congenital heart disease: a 15-year, multicenter experience of temporary and durable support

CR Broda, WC Frankel, AP Nair, WJ Dreyer… - ASAIO …, 2023 - journals.lww.com
Heart failure (HF) is common in adult congenital heart disease (ACHD) patients; however,
use of continuous-flow ventricular assist devices (CF-VADs) remains rare. We reviewed …

A novel pumping principle for a total artificial heart

T Bierewirtz, K Narayanaswamy… - IEEE Transactions …, 2023 - ieeexplore.ieee.org
Objective: Total artificial hearts (TAH) serve as a temporary treatment for severe biventricular
heart failure. The limited durability and complication rates of current devices hamper long …

Study on the hemodynamic effects of different pulsatile working modes of a rotary blood pump using a microfluidic platform that realizes in vitro cell culture effectively

L Liang, X Wang, D Chen, P Sethu, GA Giridharan… - Lab on a Chip, 2024 - pubs.rsc.org
Rotary blood pumps (RBPs) operating at a constant speed generate non-physiologic blood
pressure and flow rate, which can cause endothelial dysfunction, leading to adverse clinical …

Hemodynamic characterization of the Realheart® total artificial heart with a hybrid cardiovascular simulator

L Fresiello, A Najar, N Brynedal Ignell… - Artificial …, 2022 - Wiley Online Library
Background Heart failure is a growing health problem worldwide. Due to the lack of donor
hearts there is a need for alternative therapies, such as total artificial hearts (TAHs). The aim …

The OregonHeart total artificial heart: design and performance on a mock circulatory loop

J Glynn, H Song, B Hull, S Withers, J Gelow… - Artificial …, 2017 - Wiley Online Library
Widespread use of heart transplantation is limited by the scarcity of donor organs. Total
artificial heart (TAH) development has been pursued to address this shortage, especially to …

A physiological control method based on SMC and GAPSO for artificial heart pumps to maintain pulsatility and avoid regurgitation and suction

X Liu, H Qu, L Meng, C Wang, Q Wang - Journal of Medical and Biological …, 2023 - Springer
Purpose Artificial heart pumps are widely used for medical auxiliary blood supply, but the
existing technology has some defects. To solve the problems of traditional artificial heart …

In vitro evaluation of multi‐objective physiological control of the centrifugal blood pump

T Leao, B Utiyama, J Fonseca, E Bock… - Artificial …, 2020 - Wiley Online Library
Left ventricular assist devices (LVADs) have been used as a bridge to transplantation or as
destination therapy to treat patients with heart failure (HF). The inability of control strategy to …

A multi-objective physiological control system for continuous-flow left ventricular assist device with non-invasive physiological feedback

H Liu, S Liu - Biomedical Signal Processing and Control, 2025 - Elsevier
In order to enable continuous-flow left ventricular assist device (CFLVAD) to adjust pump
speed adaptively in response to changes in ventricular load, we developed a multi-objective …

Pulsatile vs. continuous flow

EL Wu, M Kleinheyer, A Ündar - Mechanical circulatory and respiratory …, 2018 - Elsevier
Earlier left ventricular assist devices (LVADs) were volume displacement pumps (VDPs) that
delivered pulsatile flow. However, due to improved survival rates of rotary blood pumps …