Biomolecular condensates compartmentalize and regulate assemblies of biomolecules
engaged in vital physiological processes in cells. Specific proteins and nucleic acids …

An unambiguous description of an experiment, and the subsequent biological observation,
is vital for accurate data interpretation. Minimum information guidelines define the …

Prion-like low-complexity domains (PLCDs) are involved in the formation and regulation of
distinct biomolecular condensates that form via phase separation coupled to percolation …

Sequence-ensemble relationships of intrinsically disordered proteins (IDPs) are governed
by binary patterns such as the linear clustering or mixing of specific residues or residue …

E. coli single-stranded-DNA binding protein (EcSSB) displays nearest-neighbor (NN) and
non-nearest-neighbor (NNN)) cooperativity in binding ssDNA during genome maintenance …

Cellular organization is determined by a combination of membrane-bound and membrane-
less biomolecular assemblies that range from clusters of tens of molecules to micrometer …

The lack of detailed insight into the structure of aggregates formed by the huntingtin protein
(HTT) has hampered the efforts to develop therapeutics and diagnostics targeting pathology …

Many RNA-binding proteins (RBPs) that assemble into membraneless organelles have a
common architecture including disordered prion-like domain (PLD) and folded RNA-binding …

Tardigrades are microscopic animals that survive desiccation by inducing biostasis. To
survive drying tardigrades rely on intrinsically disordered CAHS proteins, which also …

The rationale for replacing the old binary of structure–function with the trinity of structure,
disorder, and function has gained considerable ground in recent years. A continuum model …