Aminoglycosides are commonly prescribed antibiotics with deleterious side effects to the
inner ear. Due to their popular application as a result of their potent antimicrobial activities …

Myosins constitute a large superfamily of actin-dependent molecular motors. Phylogenetic
analysis currently places myosins into 15 classes. The conventional myosins which form …

Programmable RNA editing tools enable the reversible correction of mutant transcripts,
reducing the potential risk associated with permanent genetic changes associated with the …

Recent animal work has suggested that cochlear synapses are more vulnerable than hair
cells in both noise-induced and age-related hearing loss. This synaptopathy is invisible in …

The mammalian inner ear contains the cochlea and vestibular organs, which are
responsible for hearing and balance, respectively. The epithelia of these sensory organs …

The cytoskeleton is an interconnected network that provides support and organization to
cells. In eukaryotes, its main components include actin and microtubules, two types of …

Mechanotransduction—a cell's conversion of a mechanical stimulus into an electrical signal—
reveals vital features of an organism's environment. From hair cells and skin …

H+-ATPases are ubiquitous in nature; V-ATPases pump protons against an electrochemical
gradient, whereas F-ATPases reverse the process, synthesizing ATP. We demonstrate here …

Mechanical deflection of the sensory hair bundles of receptor cells in the inner ear causes
ion channels located at the tips of the bundle to open, thereby initiating the perception of …

Myosins and kinesins are molecular motors that hydrolyse ATP to track along actin filaments
and microtubules, respectively. Although the kinesin family includes motors that move …