Abstract Calcium (Ca2+) signalling is of paramount importance to immunity. Regulated
increases in cytosolic and organellar Ca2+ concentrations in lymphocytes control complex …

Store-operated calcium channels (SOCs) are a major pathway for calcium signaling in
virtually all metozoan cells and serve a wide variety of functions ranging from gene …

Store-operated calcium entry is a central mechanism in cellular calcium signalling and in
maintaining cellular calcium balance. This review traces the history of research on store …

The application of current channelrhodopsin-based optogenetic tools is limited by the lack of
strict ion selectivity and the inability to extend the spectra sensitivity into the near-infrared …

The interplay between Ca 2+ and reactive oxygen species (ROS) signaling pathways is well
established, with reciprocal regulation occurring at a number of subcellular locations. Many …

Summary Stromal-interaction molecules (STIM1/2) sense endoplasmic reticulum (ER) Ca 2+
depletion and activate Orai channels. However, the choreography of interactions between …

Specialized junctional sites that connect the plasma membrane (PM) and endoplasmic
reticulum (ER) play critical roles in controlling lipid metabolism and Ca2+ signalling,,,. Store …

Ca2+ signal-generation through inter-membrane junctional coupling between endoplasmic
reticulum (ER) STIM proteins and plasma membrane (PM) Orai channels, remains a vital but …

The gastrointestinal (GI) tract displays multiple motor patterns that move nutrients and
wastes through the body. Smooth muscle cells (SMCs) provide the forces necessary for GI …

Store-operated Ca 2+ entry mediated by STIM1 and ORAI1 constitutes one of the major Ca
2+ entry routes in mammalian cells. The molecular choreography of STIM1–ORAI1 coupling …