Breast cancer has a high occurrence rate globally and its treatment has demonstrated
clinical efficacy with the use of systemic chemotherapy and immune checkpoint blockade …

Cancer invasion and metastasis accounts for the majority of cancer related mortality. A better
understanding of the players that drive the aberrant invasion and migration of tumors cells …

BRCA1 mutations are associated with increased breast and ovarian cancer risk. BRCA1-
mutant tumors are high-grade, recurrent, and often become resistant to standard therapies …

Introduction Female-specific cancers seriously affect physical and psychological health of
women worldwide. Objectives We aimed to elucidate trends in the age-standardized …

Introduction Since the mid-2000s, breast cancer incidence among women has slowly
increased at about 0.5% per year. In the last three decades, Breast Cancer Susceptibility …

Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with inferior
outcomes owing to its low treatment response and high invasiveness. Based on abundant …

Background A growing number of studies has indicated that the expression of Breast Cancer
Susceptibility Genes 1 (BRCA1) and BRCA2 contribute to the resistance to DNA-damaging …

Simple Summary Recent estimates have shown that approx. 70% of individuals with BRCA1
mutations will develop breast cancer by the age of 70. To make matters worse, breast cancer …

Background Evidence regarding differences in survival associated with the site of metastasis
in triple-negative breast cancer (TNBC) remains limited. Our aim was to analyze the overall …

The metastasis of tumor cells into vital organs is a major cause of death from diverse types of
malignancies [1–4]. One model posits that metastasis is driven by the same oncogenic …