In the context of modeling epilepsy and neuropsychiatric comorbidities, we review the Wistar
Audiogenic Rat (WAR), first introduced to the neuroscience international community more …

Impaired consciousness during seizures severely affects quality of life for people with
epilepsy but the mechanisms are just beginning to be understood. Consciousness is thought …

Impaired breathing, cardiac function, and arousal during and after seizures are important
causes of morbidity and mortality. Previous work suggests that these changes are …

The mnemonic functions of hippocampal sharp wave ripples (SPW-Rs) have been studied
extensively. Because hippocampal outputs affect not only cortical but also subcortical …

Background Imbalanced synaptic transmission appears to be an early driver in Alzheimer's
disease (AD) leading to brain network alterations. Early detection of altered synaptic …

Sudden unexpected environmental changes capture attention and, when perceived as
potentially dangerous, evoke defensive behavioral states. Perturbations of the lateral …

The thalamus plays diverse roles in cortical-subcortical brain activity patterns. Recent work
suggests that focal temporal lobe seizures depress subcortical arousal systems and convert …

Impaired consciousness occurs suddenly and unpredictably in people with epilepsy,
markedly worsening quality of life and increasing risk of mortality. Focal seizures with …

Abstract Study Objectives Confusional arousals (CA) are characterized by the association of
behavioral awakening with persistent slow-wave electroencephalographic (EEG) activity …

The discovery of the default mode network (DMN), a large-scale brain network that is
suppressed during attention-demanding tasks, had major impact in neuroscience. This …