Clinical implications of molecular drug resistance testing for Mycobacterium tuberculosis: a 2023 TBnet/RESIST-TB consensus statement

J Domínguez, MJ Boeree, E Cambau… - The Lancet Infectious …, 2023 - thelancet.com
Drug-resistant tuberculosis is a substantial health-care concern worldwide. Despite culture-
based methods being considered the gold standard for drug susceptibility testing, molecular …

The struggle to end a millennia-long pandemic: novel candidate and repurposed drugs for the treatment of tuberculosis

BD Edwards, SK Field - Drugs, 2022 - Springer
This article provides an encompassing review of the current pipeline of putative and
developed treatments for tuberculosis, including multidrug-resistant strains. The review has …

Drug-resistant strains of Mycobacterium tuberculosis: cell envelope profiles and interactions with the host

A Schami, MN Islam, JT Belisle… - Frontiers in Cellular and …, 2023 - frontiersin.org
In the past few decades, drug-resistant (DR) strains of Mycobacterium tuberculosis (M. tb),
the causative agent of tuberculosis (TB), have become increasingly prevalent and pose a …

Nontuberculous mycobacterial resistance to antibiotics and disinfectants: challenges still ahead

S Tarashi, SD Siadat, A Fateh - BioMed Research International, 2022 - Wiley Online Library
The mortality incidence from nontuberculous mycobacteria (NTM) infections has been
steadily developing globally. These bacterial agents were once thought to be innocent …

Unraveling Dilemmas and Lacunae in the Escalating Drug Resistance of Mycobacterium tuberculosis to Bedaquiline, Delamanid, and Pretomanid

A Negi, S Perveen, R Gupta, PP Singh… - Journal of Medicinal …, 2024 - ACS Publications
Delamanid, bedaquiline, and pretomanid have been recently added in the anti-tuberculosis
(anti-TB) treatment regimens and have emerged as potential solutions for combating drug …

Nanosized Drug Delivery Systems to Fight Tuberculosis

T Bourguignon, JA Godinez-Leon, R Gref - Pharmaceutics, 2023 - mdpi.com
Tuberculosis (TB) is currently the second deadliest infectious disease. Existing
antitubercular therapies are long, complex, and have severe side effects that result in low …

Micro-nanoemulsion and nanoparticle-assisted drug delivery against drug-resistant tuberculosis: recent developments

SK Suman, N Chandrasekaran… - Clinical Microbiology …, 2023 - Am Soc Microbiol
Tuberculosis (TB) is a major global health problem and the second most prevalent infectious
killer after COVID-19. It is caused by Mycobacterium tuberculosis (Mtb) and has become …

Drug re‐engineering and repurposing: A significant and rapid approach to tuberculosis drug discovery

DS Reddy, A Sinha, A Kumar, VK Saini - Archiv der Pharmazie, 2022 - Wiley Online Library
The prevalence of tuberculosis (TB) remains the leading cause of death from a single
infectious agent, ranking it above all other contagious diseases. The problem to tackle this …

Selection of Multi-Drug Targets against Drug-Resistant Mycobacterium tuberculosis XDR1219 Using the Hyperbolic Mapping of the Protein Interaction Network

NA Zahra, AC Vagiona, R Uddin… - International Journal of …, 2023 - mdpi.com
Tuberculosis remains the leading cause of death from a single pathogen. On the other hand,
antimicrobial resistance (AMR) makes it increasingly difficult to deal with this disease. We …

Global status of phenotypic pyrazinamide resistance in Mycobacterium tuberculosis clinical isolates: an updated systematic review and meta-analysis

Z Wang, Z Tang, H Heidari, L Molaeipour… - Journal of …, 2023 - Taylor & Francis
Pyrazinamide (PZA) is an essential first-line tuberculosis drug for its unique mechanism of
action active against multidrug-resistant-TB (MDR-TB). Thus, the aim of updated meta …