Human pluripotent stem cells (hPSCs), derived from individuals or genetically modified with
disease-related mutations and variants, have revolutionised studies of human disease …

The heart is the first functional organ established during embryogenesis. Investigating heart
development and disease is a fascinating and crucial field of research because …

Abstract The National Center for Advancing Translational Sciences (NCATS) Assay
Guidance Manual (AGM) Workshop on 3D Tissue Models for Antiviral Drug Development …

Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) constitute an appealing
tool for drug discovery, disease modeling, and cardiotoxicity screening. However, their …

Human-induced stem cell-derived cardiomyocytes (hiPSC-CMs) are a valuable tool for
studying development, pharmacology, and (inherited) arrhythmias. Unfortunately, hiPSC …

A healthy heart comprises various cell types, including cardiomyocytes, endothelial cells,
fibroblasts, immune cells, and among others, which work together to maintain optimal …

Cardiovascular diseases are the leading cause of death worldwide. Several strategies–
small molecules, gene therapy, surgeries, cardiac rehabilitation–have been developed to …

The ability to engineer complex multicellular systems has enormous potential to inform our
understanding of biological processes and disease and alter the drug development process …

Myotonic dystrophy type 1 (DM1) is a genetic disorder that causes muscle weakness and
myotonia. In DM1 patients, cardiac electrical manifestations include conduction defects and …

Cardiac disorders remain the leading cause of mortality worldwide. Current clinical
strategies, including drug therapy, surgical interventions, and organ transplantation offer …