Vanadium in diabetes: 100 years from Phase 0 to Phase I

KH Thompson, C Orvig - Journal of inorganic biochemistry, 2006 - Elsevier
A little over one hundred years ago, a vanadium-containing compound was assessed
clinically for use in treatment of human diabetic patients. The results were somewhat …

[PDF][PDF] Vanadium compounds as insulin mimics

KH Thompson, JH McNeill, C Orvig - Chemical reviews, 1999 - researchgate.net
Vanadium, element number 23, atomic weight 50.94, is normally present at very low
concentrations (< 10-8 M) in virtually all cells in plants and animals. Vanadium in oxidation …

Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics.

BI Posner, R Faure, JW Burgess, AP Bevan… - Journal of Biological …, 1994 - ASBMB
Twelve peroxovanadium (pV) compounds, each containing an oxo ligand, one or two
peroxo anions, and an ancillary ligand in the inner coordination sphere of V, were …

Effects of myricetin on glycemia and glycogen metabolism in diabetic rats

KC Ong, HE Khoo - Life sciences, 2000 - Elsevier
In our previous study, we found that myricetin, a naturally occurring bioflavonoid, was able to
stimulate glucose transport in rat adipocytes and enhance insulin-stimulated lipogenesis …

Mechanisms by which carbohydrates regulate expression of genes for glycolytic and lipogenic enzymes

J Girard, P Ferré, F Foufelle - Annual review of nutrition, 1997 - annualreviews.org
▪ Abstract Regulation of gene expression by nutrients is an important mechanism in the
adaptation of mammals to their nutritional environment. This is especially true for enzymes …

Vanadium: a review of the reproductive and developmental toxicity

JL Domingo - Reproductive Toxicology, 1996 - Elsevier
While the essentiality of vanadium for living organisms has yet to be established with
certainty, vanadium has become an increasingly important environmental metal. Moreover …

Selenium, vanadium, and chromium as micronutrients to improve metabolic syndrome

SK Panchal, S Wanyonyi, L Brown - Current hypertension reports, 2017 - Springer
Trace metals play an important role in the proper functioning of carbohydrate and lipid
metabolism. Some of the trace metals are thus essential for maintaining homeostasis, while …

Insulin-mimetic effects of vanadate: possible implications for future treatment of diabetes

Y Shechter - Diabetes, 1990 - Am Diabetes Assoc
Vanadate ions, low-molecular-weight phosphate analogues, mimic most of the rapid actions
of insulin in various cell types. When administered orally to diabetic hyperglycemic rats …

Historic perspective and recent developments on the insulin-like actions of vanadium; toward developing vanadium-based drugs for diabetes

Y Shechter, I Goldwaser, M Mironchik, M Fridkin… - Coordination Chemistry …, 2003 - Elsevier
Intensive studies have been carried out during the last two decades, on the insulinomimetic
effects of vanadium. Vanadium compounds mimic most of the metabolic effects of insulin on …

Trace elements in glucometabolic disorders: an update

N Wiernsperger, JR Rapin - Diabetology & metabolic syndrome, 2010 - Springer
Many trace elements, among which metals, are indispensable for proper functioning of a
myriad of biochemical reactions, more particularly as enzyme cofactors. This is particularly …