We review the cellular and physiological mechanisms responsible for the regulation of blood
flow in the retina and choroid in health and disease. Due to the intrinsic light sensitivity of the …

Pericytes are a heterogeneous population of cells located in the blood vessel wall. They
were first identified in the 19th century by Rouget, however their biological role and potential …

In the early stages of diabetic retinopathy (DR), diabetes-related hyperglycemia directly
inhibits the AKT signaling pathway by increasing oxidative stress or inhibiting growth factor …

In this study, the effects of Baicalin on the hyperglycemia-induced cardiovascular
malformation during embryo development were investigated. Using early chick embryos, an …

Abstract Background Pericytes (PCs) are multipotent contractile cells that wrap around the
endothelial cells (ECs) to maintain the blood vessel's functionality and integrity. The …

Aim: Diabetic retinopathy causes loss of vision in adults at working-age. Few therapeutic
options are available for treatment of diabetic retinopathy. Carbamazepine (CARB), a widely …

Purpose The purpose of this study was to determine the therapeutic effect and mechanism of
AAV-MnSOD by intravitreal injection on diabetic retinopathy (DRP) and the metabolic …

The serine protease inhibitors (Serpins) represent a diverse protein superfamily that holds
paramount significance in governing vital pathophysiological processes. Their influence on …

Pericyte coverage on the endothelial tubes leads to the formation of a mature and stable
microvessel system, which is critical for brain repair after intracerebral hemorrhage (ICH) …

AIM: This study investigated the effects of pigment epithelium-derived factor (PEDF) on
advanced glycation end-product (AGE)-induced cytotoxicity in porcine retinal pericytes and …