This paper is the forty-fifth consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

Abstract Opioid Use Disorder (OUD) can be described as intense preoccupation with using
or obtaining opioids despite the negative consequences associated with their use. As the …

The search for selective opioid ligands with desired pharmacological potency and improved
safety profile has always been an area of interest. Our previous effort yielded a potent opioid …

Abstract The Department of Medicinal Chemistry, together with the Institute for Structural
Biology, Drug Discovery and Development, at Virginia Commonwealth University (VCU) has …

Despite the availability of numerous pain medications, the current array of Food and Drug
Administration-approved options falls short in adequately addressing pain states for …

While there are approved therapeutics to treat opioid overdoses, the need for treatments to
reverse overdoses due to ultrapotent fentanyls remains unmet. This may be due in part to an …

The development of highly potent and selective μ opioid receptor (MOR) modulators with
favorable drug-like properties has always been a focus in the opioid domain. Our previous …

The number of opioid-related overdose deaths and individuals that have suffered from
opioid use disorders have significantly increased over the last 30 years. FDA approved …

The morphinan skeleton is valued in drug discovery for its beneficial physicochemical
properties and is recognized as a crucial template for opioid receptor ligands. In morphinan …

This dissertation explored the potential therapeutic applications of water and methanol
extracts of C. orbiculata and Tulbaghia violacea, indigenous to Southern Africa, targeting …