Design, synthesis, in vitro and in silico studies of novel piperidine derived thiosemicarbazones as inhibitors of dihydrofolate reductase
Dihydrofolate reductase (DHFR), an essential enzyme in folate metabolism, presents a
promising target for drug development against various diseases, including cancer and …
promising target for drug development against various diseases, including cancer and …
Development of new thiazolidine-2, 4-dione hybrids as aldose reductase inhibitors endowed with antihyperglycaemic activity: design, synthesis, biological …
This research study describes the development of new small molecules based on 2, 4-
thiazolidinedione (2, 4-TZD) and their aldose reductase (AR) inhibitory activities. The …
thiazolidinedione (2, 4-TZD) and their aldose reductase (AR) inhibitory activities. The …
Development, Molecular Docking, and In Silico ADME Evaluation of Selective ALR2 Inhibitors for the Treatment of Diabetic Complications via Suppression of the …
Diabetic complications are associated with overexpression of aldose reductase, an enzyme
that catalyzes the first step of the polyol pathway. Osmotic stress in the hyperglycemic state …
that catalyzes the first step of the polyol pathway. Osmotic stress in the hyperglycemic state …
Exploration of some bis‐sulfide and bis‐sulfone derivatives as non‐classical aldose reductase inhibitors
Abstract Aldose reductase (AR, ALR2; EC 1.1. 1.21), an enzyme that converts glucose to
fructose on the polyol pathway, is an important member of the Aldo‐keto reductase …
fructose on the polyol pathway, is an important member of the Aldo‐keto reductase …
Synthesis, biological evaluation, and molecular docking study of chromen‐linked hydrazine carbothioamides as potent α‐glucosidase inhibitors
Inhibiting α‐glucosidase is a reliable method for reducing blood sugar levels in diabetic
individuals. Several novel chromen‐linked hydrazine carbothioamide (3a–r) were designed …
individuals. Several novel chromen‐linked hydrazine carbothioamide (3a–r) were designed …
Carbonyl stress chemistry
I Gordiienko, IA Gordiienko, Y Hordiienko… - 2024 - dspace.dsau.dp.ua
Exogenous and endogenous factors can induce an increase in oxidative stress, which
causes a change in the cell's redox status and is accompanied by the formation of reactive …
causes a change in the cell's redox status and is accompanied by the formation of reactive …
Assessing the Phytochemical Profile and Potential of Traditional Herbal Infusions against Aldose Reductase through In Silico Studies and LC-MS/MS Analysis
In the current market, there is a growing interest in traditional herbal nutraceuticals.
Therefore, herbal formulations have re-emerged as products with sought-after nutraceutical …
Therefore, herbal formulations have re-emerged as products with sought-after nutraceutical …
Synthesis, in vitro biological evaluation and in silico studies of novel pyrrolidine derived thiosemicarbazones as dihydrofolate reductase inhibitors
Dihydrofolate reductase (DHFR) is a crucial enzyme involved in folate metabolism and
serves as a prime target for anticancer and antimicrobial therapies. In this study, a series of 4 …
serves as a prime target for anticancer and antimicrobial therapies. In this study, a series of 4 …
Asymmetric synthesis of derivatives of alanine via Michael addition reaction and their biological study
AF Mkrtchyan, AS Tovmasyan, AM Paloyan… - Synlett, 2022 - thieme-connect.com
Ni (II) complex of the Schiff base of the chiral auxiliary (S)-2-N-(N′-benzylprolyl)
aminobenzophenone (BPB) and dehydroalanine as the initial complex in the addition …
aminobenzophenone (BPB) and dehydroalanine as the initial complex in the addition …
Okra (Abelmoschus esculentus L. moench) fruit powder standardized in flavonoids improves glycemic control and metabolic memory in acute and chronic …
APA da Silva, JX da Silva Neto, LFWG Moura… - Food Bioscience, 2024 - Elsevier
Type 2 diabetes mellitus (T2DM) is a chronic disease with high global prevalence
characterized by persistent hyperglycemia. Elevated blood glucose levels are associated …
characterized by persistent hyperglycemia. Elevated blood glucose levels are associated …