Most swimming bacteria are capable of following gradients of nutrients, signaling molecules
and other environmental factors that affect bacterial physiology. This tactic behavior became …

Bacterial pathogens have evolved a wide range of strategies to colonize and invade human
organs, despite the presence of multiple host defense mechanisms. In this review, we will …

Reproducibility in research can be compromised by both biological and technical variation,
but most of the focus is on removing the latter. Here we investigate the effects of biological …

Critical cancer pathways often cannot be targeted because of limited efficiency crossing cell
membranes. Here we report the development of a Salmonella-based intracellular delivery …

The bacterial flagellum is an amazingly complex molecular machine with a diversity of roles
in pathogenesis including reaching the optimal host site, colonization or invasion …

The gut mucosal epithelium separates the host from the microbiota, but enteropathogens
such as Salmonella Typhimurium (S. Tm) can invade and breach this barrier. Defenses …

Of the many pathogens that infect humans and animals, a large number use cells of the host
organism as protected sites for replication. To reach the relevant intracellular compartments …

Highlights•IEC invasion is a crucial step in the life cycle of non-typhoidal Salmonella.•TTSS-
1 effectors SopE/E2 and particularly SipA mediate IEC invasion in mice.•Entry structures …

The flagellum organelle is an intricate multiprotein assembly best known for its rotational
propulsion of bacteria. However, recent studies have expanded our knowledge of other …

Target-based high-throughput screening (HTS) has recently been critiqued for its relatively
poor yield compared to phenotypic screening approaches. One type of phenotypic …