Revisiting gametocyte biology in malaria parasites
P Ngotho, AB Soares, F Hentzschel… - FEMS microbiology …, 2019 - academic.oup.com
Gametocytes are the only form of the malaria parasite that is transmissible to the mosquito
vector. They are present at low levels in blood circulation and significant knowledge gaps …
vector. They are present at low levels in blood circulation and significant knowledge gaps …
Cytoskeleton organization in formation and motility of apicomplexan parasites
RG Douglas, RW Moon… - Annual Review of …, 2024 - annualreviews.org
Apicomplexan parasites are a group of eukaryotic protozoans with diverse biology that have
affected human health like no other group of parasites. These obligate intracellular parasites …
affected human health like no other group of parasites. These obligate intracellular parasites …
Variable microtubule architecture in the malaria parasite
Microtubules are a ubiquitous eukaryotic cytoskeletal element typically consisting of 13
protofilaments arranged in a hollow cylinder. This arrangement is considered the canonical …
protofilaments arranged in a hollow cylinder. This arrangement is considered the canonical …
Expansion microscopy of Plasmodium gametocytes reveals the molecular architecture of a bipartite microtubule organisation centre coordinating mitosis with …
R Rashpa, M Brochet - PLoS Pathogens, 2022 - journals.plos.org
Transmission of malaria-causing parasites to mosquitoes relies on the production of
gametocyte stages and their development into gametes. These stages display various …
gametocyte stages and their development into gametes. These stages display various …
CRISPR/Cas9-engineered inducible gametocyte producer lines as a valuable tool for Plasmodium falciparum malaria transmission research
SD Boltryk, A Passecker, A Alder, E Carrington… - Nature …, 2021 - nature.com
The malaria parasite Plasmodium falciparum replicates inside erythrocytes in the blood of
infected humans. During each replication cycle, a small proportion of parasites commits to …
infected humans. During each replication cycle, a small proportion of parasites commits to …
Repurposing the mitotic machinery to drive cellular elongation and chromatin reorganisation in Plasmodium falciparum gametocytes
The sexual stage gametocytes of the malaria parasite, Plasmodium falciparum, adopt a
falciform (crescent) shape driven by the assembly of a network of microtubules anchored to …
falciform (crescent) shape driven by the assembly of a network of microtubules anchored to …
Three-dimensional ultrastructure of Plasmodium falciparum throughout cytokinesis
RM Rudlaff, S Kraemer, J Marshman… - PLoS pathogens, 2020 - journals.plos.org
New techniques for obtaining electron microscopy data through the cell volume are being
increasingly utilized to answer cell biologic questions. Here, we present a three-dimensional …
increasingly utilized to answer cell biologic questions. Here, we present a three-dimensional …
The dynamic roles of the inner membrane complex in the multiple stages of the malaria parasite
Apicomplexan parasites, such as human malaria parasites, have complex lifecycles
encompassing multiple and diverse environmental niches. Invading, replicating, and …
encompassing multiple and diverse environmental niches. Invading, replicating, and …
The riveting cellular structures of apicomplexan parasites
CR Harding, F Frischknecht - Trends in Parasitology, 2020 - cell.com
Parasitic protozoa of the phylum Apicomplexa cause a range of human and animal
diseases. Their complex life cycles–often heteroxenous with sexual and asexual phases in …
diseases. Their complex life cycles–often heteroxenous with sexual and asexual phases in …
5-methylcytosine modification by Plasmodium NSUN2 stabilizes mRNA and mediates the development of gametocytes
5-methylcytosine (m5C) is an important epitranscriptomic modification involved in
messenger RNA (mRNA) stability and translation efficiency in various biological processes …
messenger RNA (mRNA) stability and translation efficiency in various biological processes …