Abnormalities of the endosomal–lysosomal network (ELN) are a signature feature of
Alzheimer's disease (AD). These include the earliest known cytopathology that is specific to …

Alzheimer's disease (AD) constitutes the most prominent form of dementia among elderly
individuals worldwide. Disease modeling using murine transgenic mice was first initiated …

Abstract Background Loss of the Sortilin-related receptor 1 (SORL1) gene seems to act as a
causal event for Alzheimer's disease (AD). Recent studies have established that loss of …

Progression of brain ageing is influenced by a complex interaction of genetic and
environmental factors. Analysis of genetically modified animals with uniform genetic …

Individuals with Down syndrome (DS) have an increased risk of early-onset Alzheimer's
Disease (AD), largely owing to a triplication of the APP gene, located on chromosome 21. In …

The distinctive morphology of neurons, with complex dendritic arbors and extensive axons,
presents spatial challenges for intracellular signal transduction. The endosomal system …

Emerging evidence suggests that aberrant phosphorylation of eukaryotic initiation factor-2α
(eIF2α) may induce synaptic failure and neurodegeneration through persistent translational …

Possession of the ε4 allele of apolipoprotein E (APOE) is the major genetic risk factor for late-
onset Alzheimer's disease (AD). Although numerous hypotheses have been proposed, the …

Transgenic mouse models represent an essential tool for the exploration of Alzheimer's
disease (AD) pathological mechanisms and the development of novel treatments, which at …

Abstract β-amyloid precursor protein (APP) and amyloid beta peptide (Aβ) are strongly
implicated in Alzheimer's disease (AD) pathogenesis, although recent evidence has linked …