Role of CCL2/CCR2 axis in the immunopathogenesis of rheumatoid arthritis: Latest evidence and therapeutic approaches

F Moadab, H Khorramdelazad, M Abbasifard - Life Sciences, 2021 - Elsevier
Evidence suggests that uncontrolled immune system responses and their components play
a significant role in developing rheumatoid arthritis (RA), which is considered an …

Therapeutic potential of Coptis chinensis for arthritis with underlying mechanisms

M Li, F Tian, J Guo, X Li, L Ma, M Jiang… - Frontiers in …, 2023 - frontiersin.org
Arthritis is a common degenerative disease of joints, which has become a public health
problem affecting human health, but its pathogenesis is complex and cannot be eradicated …

Building a modular and multi-cellular virtual twin of the synovial joint in Rheumatoid Arthritis

N Zerrouk, F Augé, A Niarakis - npj Digital Medicine, 2024 - nature.com
Rheumatoid arthritis is a complex disease marked by joint pain, stiffness, swelling, and
chronic synovitis, arising from the dysregulated interaction between synoviocytes and …

Artemisia argyi extract ameliorates IL‐17A‐induced inflammatory response by regulation of NF‐κB and Nrf2 expression in HIG‐82 synoviocytes

JK Chen, CH Kuo, WW Kuo, CH Day… - Environmental …, 2022 - Wiley Online Library
Rheumatoid arthritis (RA) is an autoimmune and chronic inflammatory disease that results in
joint destruction and disability in the adult population. RA is characterized by the …

IL‑1β increases the expression of inflammatory factors in synovial fluid‑derived fibroblast‑like synoviocytes via activation of the NF‑κB‑mediated ERK‑STAT1 signaling …

J Yang, J Wang, X Liang, H Zhao… - Molecular …, 2019 - spandidos-publications.com
Abstract Interleukin (IL)‑1β serves a crucial role in the progression of rheumatoid arthritis.
Previous studies have indicated that the ERK/STAT1 signaling pathway may be involved in …

[HTML][HTML] The mechanism of the anti-inflammatory effect of Oldenlandia diffusa on arthritis model rats: a quantitative proteomic and network pharmacologic study

H Zhu, XG Xiong, Y Lu, HC Wu, ZH Zhang… - Annals of Translational …, 2022 - ncbi.nlm.nih.gov
Background In China, Oldenlandia diffusa (OD) has been prescribed as a therapeutic herb
for rheumatoid arthritis (RA). We previously conducted a preliminary study of the anti …

Ohwia caudata extract relieves the IL‐17A‐induced inflammatory response of synoviocytes through modulation of SOCS3 and JAK2/STAT3 activation

CY Lu, CH Kuo, WW Kuo, DJY Hsieh… - Environmental …, 2023 - Wiley Online Library
Fibroblast‐like synoviocytes accumulation, proliferation and activation, and the subsequent
inflammatory mediators production play a key role in the progression of rheumatoid arthritis …

Exploring the role of monocyte chemoattractant protein-1 in fibroblast-like synovial cells in rheumatoid arthritis

X Tong, D Yu, L Yu, W Chen, Y Wen, P Gu - PeerJ, 2021 - peerj.com
Background Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease with
persistent synovitis. In the present study, the impact of monocyte chemoattractant protein-1 …

Circulating Serum Caveolin-1 and Interleukin-37 as Predictive Biomarkers in Rheumatoid Arthritis Patients

IM Mohammed, IMAA Mashkor, SA Alsalimi… - Journal of Natural …, 2024 - jnsbm.org
Background: The immune system mistakenly attacks healthy tissues in rheumatoid arthritis
(RA), causing a cascade of symptoms such as joint pain, swelling, stiffness, and even …

[引用][C] The distinct and aggressive pathogenesis of arthritis in children with Down syndrome

SSY Foo - 2023 - School of Medicine, Trinity College …