Successful launch of a commercial drug requires significant investment of time and financial resources wherein late-stage failures become a reason for catastrophic failures in drug …
We present a new strategy for the fabrication of artificial skeletal muscle tissue with functional morphologies based on an innovative 3D bioprinting approach. The methodology …
Improving the ability to predict the efficacy and toxicity of drug candidates earlier in the drug discovery process will speed up the introduction of new drugs into clinics. 3D in vitro …
L Yu, S Cavelier, B Hannon, M Wei - Bioactive Materials, 2023 - Elsevier
Osteochondral (OC) repair is an extremely challenging topic due to the complex biphasic structure and poor intrinsic regenerative capability of natural osteochondral tissue. In …
Y Liu, G Zhou, Y Cao - Engineering, 2017 - Elsevier
Given the limited spontaneous repair that follows cartilage injury, demand is growing for tissue engineering approaches for cartilage regeneration. There are two major applications …
T Garg, AK Goyal - Expert opinion on drug delivery, 2014 - Taylor & Francis
Introduction: Biomaterial-based scaffold formulations (three-dimensional Porous matrix, nano-fibre mesh, hydrogels and microspheres) are the major components that are used to …
P De Stefano, E Bianchi, G Dubini - Biomicrofluidics, 2022 - pubs.aip.org
Drug discovery is an expensive and lengthy process. Among the different phases, drug discovery and preclinical trials play an important role as only 5–10 of all drugs that begin …
JD Green, V Tollemar, M Dougherty, Z Yan, L Yin, J Ye… - Genes & diseases, 2015 - Elsevier
Defects of articular cartilage present a unique clinical challenge due to its poor self-healing capacity and avascular nature. Current surgical treatment options do not ensure consistent …
FL Ronzoni, F Aliberti, F Scocozza… - Journal of Tissue …, 2022 - Wiley Online Library
Skeletal muscle regeneration is one of the major areas of interest in sport medicine as well as trauma centers. Three‐dimensional (3D) bioprinting (BioP) is nowadays widely adopted …