A substantial portion of metabolism involves transformation of phosphate esters, including
pathways leading to nucleotides and oligonucleotides, carbohydrates, isoprenoids and …

To address the continued rise of multi-drug-resistant microorganisms, the development of
novel drugs with new modes of action is urgently required. While humans biosynthesize the …

Antimicrobial drug resistance is an urgent problem in the control and treatment of many of
the world's most serious infections, including Plasmodium falciparum malaria, tuberculosis …

Important pathogens such as Mycobacterium tuberculosis and Plasmodium falciparum, the
causative agents of tuberculosis and malaria, respectively, and plants, utilize the 2 C-methyl …

The human malaria parasite Plasmodium falciparum is responsible for the deaths of more
than a million people each year. Fosmidomycin has been proven to be efficient in the …

The biological activity and natural occurrence of the aminophosphonic acids were described
half a century ago. Since then the chemistry and biology of this class of compounds have …

The nonmevalonate pathway (NMP) of isoprene biosynthesis is an exciting new route
toward novel antibiotic development. Inhibitors against several enzymes in this pathway are …

Isoprene biosynthesis is an essential component of metabolism. Two pathways are known
for the production of five-carbon (isoprene) intermediates: the mevalonate and …

Introduction: The relict plastid, or apicoplast, is a characteristic feature of Plasmodium spp.
and reflects the unusual evolutionary origins of these parasites. The essential role this …

Reverse hydroxamate-based inhibitors of IspC, a key enzyme of the non-mevalonate
pathway of isoprenoid biosynthesis and a validated antimalarial target, were synthesized …