The complexity of Alzheimer's disease: an evolving puzzle
The history of Alzheimer's disease (AD) started in 1907, but we needed to wait until the end
of the century to identify the components of pathological hallmarks and genetic subtypes and …
of the century to identify the components of pathological hallmarks and genetic subtypes and …
Neuroimaging in dementia: more than typical Alzheimer disease
Alzheimer disease (AD) is the most common cause of dementia. The prevailing theory of the
underlying pathology assumes amyloid accumulation followed by tau protein aggregation …
underlying pathology assumes amyloid accumulation followed by tau protein aggregation …
Prospective longitudinal atrophy in Alzheimer's disease correlates with the intensity and topography of baseline tau-PET
β-Amyloid plaques and tau-containing neurofibrillary tangles are the two neuropathological
hallmarks of Alzheimer's disease (AD) and are thought to play crucial roles in a …
hallmarks of Alzheimer's disease (AD) and are thought to play crucial roles in a …
Comorbid neuropathological diagnoses in early versus late-onset Alzheimer's disease
Co-pathologies play an important role in the expression of the Alzheimer's disease clinical
phenotype and may influence treatment efficacy. Early-onset Alzheimer's disease, defined …
phenotype and may influence treatment efficacy. Early-onset Alzheimer's disease, defined …
Research criteria for the behavioral variant of Alzheimer disease: a systematic review and meta-analysis
R Ossenkoppele, EH Singleton, C Groot… - JAMA …, 2022 - jamanetwork.com
Importance The behavioral variant of Alzheimer disease (bvAD) is characterized by early
and predominant behavioral deficits caused by AD pathology. This AD phenotype is …
and predominant behavioral deficits caused by AD pathology. This AD phenotype is …
Retinal changes in Alzheimer's disease—integrated prospects of imaging, functional and molecular advances
Alzheimer's Disease (AD) is a devastating neurodegenerative disorder of the brain, clinically
characterised by cognitive deficits that gradually worsen over time. There is, at present, no …
characterised by cognitive deficits that gradually worsen over time. There is, at present, no …
Progressive dysexecutive syndrome due to Alzheimer's disease: a description of 55 cases and comparison to other phenotypes
RA Townley, J Graff-Radford, WG Mantyh… - Brain …, 2020 - academic.oup.com
We report a group of patients presenting with a progressive dementia syndrome
characterized by predominant dysfunction in core executive functions, relatively young age …
characterized by predominant dysfunction in core executive functions, relatively young age …
Alzheimer's disease including focal presentations
Alzheimer's disease (AD) is the commonest neurodegenerative disease and the most
frequent cause of dementia. It affects 30 million people worldwide. Current research criteria …
frequent cause of dementia. It affects 30 million people worldwide. Current research criteria …
Deciphering the clinico-radiological heterogeneity of dysexecutive Alzheimer's disease
Dysexecutive Alzheimer's disease (dAD) manifests as a progressive dysexecutive syndrome
without prominent behavioral features, and previous studies suggest clinico-radiological …
without prominent behavioral features, and previous studies suggest clinico-radiological …
Pathobiological subtypes of Alzheimer disease
KA Jellinger - Dementia and Geriatric Cognitive Disorders, 2021 - karger.com
Alzheimer disease (AD), the most common form of dementia, is a heterogenous disorder
with various pathobiological subtypes. In addition to the 4 major subtypes based on the …
with various pathobiological subtypes. In addition to the 4 major subtypes based on the …