Animal models for COVID-19: advances, gaps and perspectives
C Fan, Y Wu, X Rui, Y Yang, C Ling, S Liu… - Signal transduction and …, 2022 - nature.com
Abstract COVID-19, caused by SARS-CoV-2, is the most consequential pandemic of this
century. Since the outbreak in late 2019, animal models have been playing crucial roles in …
century. Since the outbreak in late 2019, animal models have been playing crucial roles in …
New avenues for the treatment of Huntington's disease
A Kim, K Lalonde, A Truesdell, P Gomes Welter… - International journal of …, 2021 - mdpi.com
Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG expansion in
the HD gene. The disease is characterized by neurodegeneration, particularly in the striatum …
the HD gene. The disease is characterized by neurodegeneration, particularly in the striatum …
Antisense oligonucleotide therapy: from design to the Huntington disease clinic
ME Rook, AL Southwell - BioDrugs, 2022 - Springer
Huntington disease (HD) is a fatal progressive neurodegenerative disorder caused by an
inherited mutation in the huntingtin (HTT) gene, which encodes mutant HTT protein. Though …
inherited mutation in the huntingtin (HTT) gene, which encodes mutant HTT protein. Though …
Choosing an animal model for the study of Huntington's disease
MA Pouladi, AJ Morton, MR Hayden - Nature Reviews Neuroscience, 2013 - nature.com
Since the identification of the causative gene in Huntington's disease (HD), a number of
animal models of this disorder have been developed. A frequently asked question is: which …
animal models of this disorder have been developed. A frequently asked question is: which …
Small molecule splicing modifiers with systemic HTT-lowering activity
A Bhattacharyya, CR Trotta, J Narasimhan… - Nature …, 2021 - nature.com
Huntington's disease (HD) is a hereditary neurodegenerative disorder caused by expansion
of cytosine-adenine-guanine (CAG) trinucleotide repeats in the huntingtin (HTT) gene …
of cytosine-adenine-guanine (CAG) trinucleotide repeats in the huntingtin (HTT) gene …
Huntingtin and the Synapse
Huntington disease (HD) is a monogenic disease that results in a combination of motor,
psychiatric and cognitive symptoms. HD is caused by a CAG trinucleotide repeat expansion …
psychiatric and cognitive symptoms. HD is caused by a CAG trinucleotide repeat expansion …
Human mesenchymal stem cells genetically engineered to overexpress brain-derived neurotrophic factor improve outcomes in Huntington's disease mouse models
K Pollock, H Dahlenburg, H Nelson, KD Fink, W Cary… - Molecular Therapy, 2016 - cell.com
Huntington's disease (HD) is a fatal degenerative autosomal dominant neuropsychiatric
disease that causes neuronal death and is characterized by progressive striatal and then …
disease that causes neuronal death and is characterized by progressive striatal and then …
Huntingtin suppression restores cognitive function in a mouse model of Huntington's disease
AL Southwell, HB Kordasiewicz, D Langbehn… - Science translational …, 2018 - science.org
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by
a mutation in the huntingtin (HTT) protein, resulting in acquisition of toxic functions. Previous …
a mutation in the huntingtin (HTT) protein, resulting in acquisition of toxic functions. Previous …
Alterations in synaptic function and plasticity in Huntington disease
AI Smith‐Dijak, MD Sepers… - Journal of …, 2019 - Wiley Online Library
Huntington disease (HD) is an inherited neurodegenerative disorder caused by an
expansion of the CAG repeat region in the first exon of the huntingtin gene …
expansion of the CAG repeat region in the first exon of the huntingtin gene …
Mutant huntingtin is cleared from the brain via active mechanisms in Huntington disease
Huntington disease (HD) is a neurodegenerative disease caused by a CAG trinucleotide
repeat expansion in the huntingtin (HTT) gene. Therapeutics that lower HTT have shown …
repeat expansion in the huntingtin (HTT) gene. Therapeutics that lower HTT have shown …