Pharmacotherapeutic approaches to treatment of muscular dystrophies
A Rawls, BK Diviak, CI Smith, GW Severson, SA Acosta… - Biomolecules, 2023 - mdpi.com
Muscular dystrophies are a heterogeneous group of genetic muscle-wasting disorders that
are subdivided based on the region of the body impacted by muscle weakness as well as …
are subdivided based on the region of the body impacted by muscle weakness as well as …
[HTML][HTML] Pervasive nuclear envelope ruptures precede ECM signaling and disease onset without activating cGAS-STING in Lamin-cardiomyopathy mice
A En, H Bogireddi, B Thomas, AV Stutzman, S Ikegami… - Cell Reports, 2024 - cell.com
Nuclear envelope (NE) ruptures are emerging observations in Lamin-related dilated
cardiomyopathy, an adult-onset disease caused by loss-of-function mutations in Lamin A/C …
cardiomyopathy, an adult-onset disease caused by loss-of-function mutations in Lamin A/C …
[PDF][PDF] The cGAS-STING pathway is dispensable in a mouse model of LMNA -cardiomyopathy despite nuclear envelope rupture.
A En, H Bogireddi, B Thomas, A Stutzman… - Biorxiv: the Preprint …, 2023 - researchgate.net
Mutations in the nuclear Lamin A/C gene (LMNA) cause diverse degenerative disorders,
including malignant dilated cardiomyopathy in adults. A prevailing hypothesis postulates …
including malignant dilated cardiomyopathy in adults. A prevailing hypothesis postulates …
Recent insights in striated muscle laminopathies
M Leconte, G Bonne, AT Bertrand - Current Opinion in Neurology - journals.lww.com
Since the first LMNA mutation report in 1999, lamin A/C structure and functions have been
actively explored to understand the SML pathophysiology. The latest discoveries of partners …
actively explored to understand the SML pathophysiology. The latest discoveries of partners …
The resistance of circulating tumor cells to large fluid shear stress in hematogenous dissemination by reducing mechanosensitivity via nuclear mechanosensing …
C Zhang - 2024 - theses.lib.polyu.edu.hk
Tumor cells metastasize to distant organs mainly through hematogenous dissemination,
where circulating tumor cells (CTCs) experience varying levels of fluid shear stress (FSS) in …
where circulating tumor cells (CTCs) experience varying levels of fluid shear stress (FSS) in …