[HTML][HTML] Protein post-translational modifications: In silico prediction tools and molecular modeling

M Audagnotto, M Dal Peraro - Computational and structural biotechnology …, 2017 - Elsevier
Post-translational modifications (PTMs) occur in almost all proteins and play an important
role in numerous biological processes by significantly affecting proteins' structure and …

The regulation of protein phosphorylation

LN Johnson - Biochemical Society Transactions, 2009 - portlandpress.com
Phosphorylation plays essential roles in nearly every aspect of cell life. Protein kinases
regulate signalling pathways and cellular processes that mediate metabolism, transcription …

[HTML][HTML] Cryo-electron microscopy and X-ray crystallography: complementary approaches to structural biology and drug discovery

C Vénien-Bryan, Z Li, L Vuillard… - … Section F: Structural …, 2017 - scripts.iucr.org
The invention of the electron microscope has greatly enhanced the view scientists have of
small structural details. Since its implementation, this technology has undergone …

The regulation of glycogenolysis in the brain

OW Nadeau, JD Fontes, GM Carlson - Journal of Biological Chemistry, 2018 - ASBMB
The key regulatory enzymes of glycogenolysis are phosphorylase kinase, a hetero-oligomer
with four different types of subunits, and glycogen phosphorylase, a homodimer. Both …

Kinetics, in silico docking, molecular dynamics, and MM‐GBSA binding studies on prototype indirubins, KT5720, and staurosporine as phosphorylase kinase ATP …

JM Hayes, VT Skamnaki, G Archontis… - Proteins: Structure …, 2011 - Wiley Online Library
With an aim toward glycogenolysis control in Type 2 diabetes, we have investigated via
kinetic experiments and computation the potential of indirubin (IC50> 50 lM), indirubin-3 0 …

[图书][B] Optical and digital image processing: fundamentals and applications

G Cristóbal, P Schelkens, H Thienpont - 2013 - books.google.com
In recent years, Moore's law has fostered the steady growth of the field of digital image
processing, though the computational complexity remains a problem for most of the digital …

Brain glycogen structure and its associated proteins: past, present and future

MK Brewer, MS Gentry - Brain glycogen metabolism, 2019 - Springer
Brain Glycogen Structure and Its Associated Proteins: Past, Present and Future | SpringerLink
Skip to main content Advertisement SpringerLink Account Menu Find a journal Publish with us …

Molecular basis of the death-associated protein kinase–calcium/calmodulin regulator complex

I de Diego, J Kuper, N Bakalova, P Kursula… - Science …, 2010 - science.org
Death-associated protein kinase (DAPK) provides a model for calcium-bound calmodulin
(CaM)–dependent protein kinases (CaMKs). Here, we report the crystal structure of the …

Architecture and activation of human muscle phosphorylase kinase

X Yang, M Zhu, X Lu, Y Wang, J Xiao - Nature Communications, 2024 - nature.com
The study of phosphorylase kinase (PhK)-regulated glycogen metabolism has contributed to
the fundamental understanding of protein phosphorylation; however, the molecular …

Education catching up with science: Preparing students for three-dimensional literacy in cell biology

IJM Kramer, HR Dahmani, P Delouche… - CBE—Life Sciences …, 2012 - Am Soc Cell Biol
The large number of experimentally determined molecular structures has led to the
development of a new semiotic system in the life sciences, with increasing use of accurate …