Protein misfolding, aggregation and mechanism of amyloid cytotoxicity: An overview and therapeutic strategies to inhibit aggregation
Protein and peptides are converted from their soluble forms into highly ordered fibrillar
aggregates under various conditions inside the cell. Such transitions confer diverse …
aggregates under various conditions inside the cell. Such transitions confer diverse …
Vitamin k3 inhibits protein aggregation: implication in the treatment of amyloid diseases
Protein misfolding and aggregation have been associated with several human diseases
such as Alzheimer's, Parkinson's and familial amyloid polyneuropathy etc. In this study, anti …
such as Alzheimer's, Parkinson's and familial amyloid polyneuropathy etc. In this study, anti …
Protein folding, misfolding and aggregation: A tale of constructive to destructive assembly
The newly synthesized unfolded polypeptide attains its functional and unique three-
dimensional conformation through the process of protein folding for which several models …
dimensional conformation through the process of protein folding for which several models …
Biophysical insight into the anti-amyloidogenic behavior of taurine
In this work, we investigated the inhibitory ability of taurine on the aggregation of Human
serum albumin (HSA) and also examined how it controls the kinetic parameters of the …
serum albumin (HSA) and also examined how it controls the kinetic parameters of the …
Unraveling comparative anti-amyloidogenic behavior of pyrazinamide and D-cycloserine: a mechanistic biophysical insight
SK Chaturvedi, N Zaidi, P Alam, JM Khan, A Qadeer… - PloS one, 2015 - journals.plos.org
Amyloid fibril formation by proteins leads to variety of degenerative disorders called
amyloidosis. While these disorders are topic of extensive research, effective treatments are …
amyloidosis. While these disorders are topic of extensive research, effective treatments are …
Effect of 1-methyl-3-octyleimmidazolium chloride on the stability and activity of lysozyme: a spectroscopic and molecular dynamics studies
M Kumari, N Dohare, N Maurya… - Journal of …, 2017 - Taylor & Francis
Herein, the binding of 1-methyl-3-octylimidazolium chloride [OMIM][Cl] ionic liquid with hen
egg white lysozyme (HEWL) has been studied using fluorescence, time resolved …
egg white lysozyme (HEWL) has been studied using fluorescence, time resolved …
Myricetin prevents fibrillogenesis of hen egg white lysozyme
J He, Y Wang, AK Chang, L Xu, N Wang… - Journal of agricultural …, 2014 - ACS Publications
Myricetin is a natural flavonol found in many grapes, berries, fruits, vegetables, and herbs as
well as other plants. Recent studies have identified potential antiamyloidogenic activity for …
well as other plants. Recent studies have identified potential antiamyloidogenic activity for …
Elevated temperatures accelerate the formation of toxic amyloid fibrils of hen egg‐white lysozyme
Z Feng, Y Li, Y Bai - Veterinary Medicine and Science, 2021 - Wiley Online Library
The formation of amyloid fibrils is critical for neurodegenerative diseases. Some
physiochemical conditions can promote the conversion of proteins from soluble globular …
physiochemical conditions can promote the conversion of proteins from soluble globular …
Anti-fibrillation propensity of a flavonoid baicalein against the fibrils of hen egg white lysozyme: potential therapeutics for lysozyme amyloidosis
More than 20 human diseases involve the fibrillation of a specific protein/peptide which
forms pathological deposits at various sites. Hereditary lysozyme amyloidosis is a systemic …
forms pathological deposits at various sites. Hereditary lysozyme amyloidosis is a systemic …
An antibiotic (sulfamethoxazole) stabilizes polypeptide (human serum albumin) even under extreme condition (elevated temperature)
Since aggregation of protein result into number of human diseases including diabetes
mellitus, Huntington's and Alzheimer's disease, etc. Hence prevention of aggregation of a …
mellitus, Huntington's and Alzheimer's disease, etc. Hence prevention of aggregation of a …