In many natural and clinical settings, bacteria are associated with some type of biotic or
abiotic surface that enables them to form biofilms, a multicellular lifestyle with bacteria …

Biofilms consist of microbial communities embedded in a 3D extracellular matrix. The matrix
is composed of a complex array of extracellular polymeric substances (EPS) that contribute …

Foot infections are the main disabling complication in patients with diabetes mellitus. These
infections can lead to lower-limb amputation, increasing mortality and decreasing the quality …

Abstract Autoinducer-2 (AI-2) is a quorum sensing signal that mediates communication
within and between many bacterial species. However, its known receptors (LuxP and LsrB …

Pseudomonas aeruginosa biofilms and the capacity of the bacterium to coexist and interact
with a broad range of microorganisms have a substantial clinical impact. This review focuses …

Many bacteria use a cell-cell communication system called quorum sensing to coordinate
population density-dependent changes in behavior. Quorum sensing involves production of …

Biofilms are population of cells growing in a coordinated manner and exhibiting resistance
towards hostile environments. The infections associated with biofilms are difficult to control …

A chronic wound is a serious complication associated with diabetes mellitus and is difficult to
heal due to high glucose levels, oxidative stress, and biofilm-associated microbial infection …

Many microbial communities, including those involved in chronic human infections, are
patterned at the micron scale. In this Review, we summarize recent work that has defined the …

Pyocyanin was the first natural phenazine described. The molecule is synthesized by about
95% of the strains of Pseudomonas aeruginosa. From discovery up to now, pyocyanin has …