Background Circadian rhythms are important for all aspects of biology; virtually every aspect
of biological function varies according to time of day. Although this is well known, variation …

The circadian system in the human body responds to daily environmental changes to
optimise behaviour according to the biological clock and also influences various …

Nearly all physiological and behavioral processes display daily rhythms driven by
endogenous circadian clocks—molecular representations of the external solar day …

Cardiovascular diseases are the top cause of mortality in the United States, and ischemic
heart disease accounts for 16% of all deaths around the world. Modifiable risk factors such …

Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease
in the world and one of the leading indications for liver transplantation. It is one of the many …

A wealth of data is available from electronic health records (EHR) that are collected as part
of routine clinical care in hospitals worldwide. These rich, longitudinal data offer an attractive …

Dependence of pharmacokinetics and drug effects (efficacy and toxicity) on dosing time has
long been recognized. However, significant progress has only recently been made in our …

Circadian rhythm perturbations can impact the evolution of different conditions, including
autoimmune diseases. This narrative review summarizes the current understanding of …

Research over the last 20 years regarding the link between circadian rhythms and chronic
pain pathology has suggested interconnected mechanisms that are not fully understood …

Although vancomycin (VCM)—frequently used to treat drug-resistant bacterial infections—
often induces acute kidney injury (AKI), discontinuation of the drug is the only effective …