Genetic background of febrile seizures

A Saghazadeh, M Mastrangelo… - Reviews in the …, 2014 - degruyter.com
Febrile seizures (FSs) occur in children older than 1 month and without prior afebrile
seizures in the absence of a central nervous system infection or acute electrolyte imbalance …

Generation of febrile seizures and subsequent epileptogenesis

B Feng, Z Chen - Neuroscience bulletin, 2016 - Springer
Febrile seizures (FSs) occur commonly in children aged from 6 months to 5 years. Complex
(repetitive or prolonged) FSs, but not simple FSs, can lead to permanent brain modification …

Genome-wide association study of febrile seizures implicates fever response and neuronal excitability genes

L Skotte, J Fadista, J Bybjerg-Grauholm, V Appadurai… - Brain, 2022 - academic.oup.com
Febrile seizures represent the most common type of pathological brain activity in young
children and are influenced by genetic, environmental and developmental factors. In a …

Plasma cytokines associated with febrile status epilepticus in children: a potential biomarker for acute hippocampal injury

WB Gallentine, S Shinnar, DC Hesdorffer, L Epstein… - …, 2017 - Wiley Online Library
Objective Our aim was to explore the association between plasma cytokines and febrile
status epilepticus (FSE) in children, as well as their potential as biomarkers of acute …

[HTML][HTML] Causality assessment of adverse events following immunization: the problem of multifactorial pathology

P Bellavite - F1000Research, 2020 - ncbi.nlm.nih.gov
Abstract The analysis of Adverse Events Following Immunization (AEFI) is important in a
balanced epidemiological evaluation of vaccines and in the issues related to vaccine injury …

Analysis of plasma multiplex cytokines and increased level of IL-10 and IL-1Ra cytokines in febrile seizures

K Kim, BO Kwak, A Kwon, J Ha, SJ Kim, SW Bae… - Journal of …, 2017 - Springer
Background Febrile seizures are the most common form of childhood seizures. Fever
generation involves many cytokines, including both pro-and anti-inflammatory cytokines …

Lipopolysaccharide potentiates hyperthermia‐induced seizures

BL Eun, J Abraham, L Mlsna, MJ Kim… - Brain and behavior, 2015 - Wiley Online Library
Background Prolonged febrile seizures (FS) have both acute and long‐lasting effects on the
developing brain. Because FS are often associated with peripheral infection, we aimed to …

Familial mesial temporal lobe epilepsy: clinical spectrum and genetic evidence for a polygenic architecture

RV Harris, KL Oliver, P Perucca, P Striano… - Annals of …, 2023 - Wiley Online Library
Objective Familial mesial temporal lobe epilepsy (FMTLE) is an important focal epilepsy
syndrome; its molecular genetic basis is unknown. Clinical descriptions of FMTLE vary …

Cysteinyl leukotriene receptor (CysLT) antagonists decrease pentylenetetrazol-induced seizures and blood–brain barrier dysfunction

QF Lenz, DS Arroyo, FR Temp, AB Poersch… - Neuroscience, 2014 - Elsevier
Current evidence suggests that inflammation plays a role in the pathophysiology of seizures.
In line with this view, selected pro-inflammatory arachidonic acid derivatives have been …

Association between interleukin-6 gene polymorphisms and febrile seizure risk: a meta-analysis

Q Chen, M Li, X Zhang, X Zhang, R Zhong, W Lin - Medicine, 2019 - journals.lww.com
Background: The association between plasma interleukin-6 (IL-6) levels and the
development of febrile seizures (FS) has been reported in multiple previous studies, which …