Metformin: an old drug with new applications

J Zhou, S Massey, D Story, L Li - International journal of molecular …, 2018 - mdpi.com
Metformin is a biguanide drug that has been used to treat type 2 diabetes mellitus for more
than 60 years. The United Kingdom Prospective Diabetic Study (UKPDS) has shown …

[HTML][HTML] Role of gut microbiota and oxidative stress in the progression of non-alcoholic fatty liver disease to hepatocarcinoma: Current and innovative therapeutic …

A Borrelli, P Bonelli, FM Tuccillo, ID Goldfine, JL Evans… - Redox biology, 2018 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) represents the most common chronic liver disease
in industrialized countries. NAFLD progresses through the inflammatory phase of non …

Diabetes and beta cell function: from mechanisms to evaluation and clinical implications

S Cernea, M Dobreanu - Biochemia medica, 2013 - hrcak.srce.hr
Sažetak Diabetes is a complex, heterogeneous condition that has beta cell dysfunction at its
core. Many factors (eg hyperglycemia/glucotoxicity, lipotoxicity, autoimmunity, inflammation …

Predictors and prevention of diabetic cardiomyopathy

V Chavali, SC Tyagi, PK Mishra - Diabetes, metabolic syndrome …, 2013 - Taylor & Francis
Despite our cognizance that diabetes can enhance the chances of heart failure, causes
multiorgan failure, and contributes to morbidity and mortality, it is rapidly increasing menace …

Role of oxidative stress in metabolic and subcellular abnormalities in diabetic cardiomyopathy

NS Dhalla, AK Shah, PS Tappia - International journal of molecular …, 2020 - mdpi.com
Although the presence of cardiac dysfunction and cardiomyopathy in chronic diabetes has
been recognized, the pathophysiology of diabetes-induced metabolic and subcellular …

Combination therapy of metformin and p-coumaric acid mitigates metabolic dysfunction associated with obesity and nonalcoholic fatty liver disease in high-fat diet …

G Goodarzi, SS Tehrani, G Panahi… - The Journal of …, 2023 - Elsevier
Metformin (MET) has been demonstrated to have favorable impact on nonalcoholic fatty liver
disease (NAFLD); however, the combined effect of this drug with p-coumaric acid (PCA) on …

[HTML][HTML] Antidiabetic potential of methanolic and flavonoid-rich leaf extracts of Synsepalum dulcificum in type 2 diabetic rats

TO Obafemi, AC Akinmoladun, MT Olaleye… - Journal of Ayurveda and …, 2017 - Elsevier
Background Synsepalum dulcificum is a plant indigenous to West Africa. The fruit is used to
modify taste of foods to sweetness. Objectives This study aims to investigate the antidiabetic …

[PDF][PDF] Antioxidants and lipid peroxidation status in diabetic patients with and without complications

R Srivatsan, S Das, R Gadde, KK MANOJ, S Taduri… - 2009 - sid.ir
Background: Oxidative stress is involved in the pathophysiology of diabetes mellitus.
Methods: In the present study, 68 patients with type 2 diabetes mellitus and 31 clinically …

An overview of the health benefits of Prunus species with special reference to metabolic syndrome risk factors

H Ullah, A De Filippis, H Khan, J Xiao… - Food and chemical …, 2020 - Elsevier
Metabolic syndrome is a cluster of pathologies and conditions such as obesity,
hyperglycemia, hyperlipidemia and hypertension representing a serious health concern in …

Insulin sensitizers prevent fine particulate matter-induced vascular insulin resistance and changes in endothelial progenitor cell homeostasis

P Haberzettl, JP McCracken… - American Journal of …, 2016 - journals.physiology.org
Exposure to fine particular matter (PM2. 5) increases the risk of developing cardiovascular
disease and Type 2 diabetes. Because blood vessels are sensitive targets of air pollutant …